Publikationen

Simone Schierle, Cahtrin Flauaus, Pascal Heitel, Sabine Willems, Astrid Kaiser, Lilia Weizel, Tamara Göbel, Astrid Stefanie Kahnt, Gerd Geisslinger, Dieter Steinhilber, Mario Wurglics, G. Enrico Rovati, Achim Schmidtko, Eugen Proschak, Daniel Merk

Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology.

2018, Journal of Medicinal Chemistry

Sandra Pierre, Dong Dong Zhang, Jing Suo, Katharina Kern, Neda Tarighi, Klaus Scholich

Myc binding protein 2 suppresses M2-like phenotypes in macrophages during zymosan-induced inflammation in mice.

2018, European Journal of Immunology

Jörn Lötsch, Iris Weyer-Menkhoff, Irmgard Tegeder

Current evidence of cannabinoid-based analgesia obtained in preclinical and human experimental settings.

2018, European Journal of Pain

Leonard Blum, Susanne Schiffmann, Michael J. Parnham

Immunomodulation by antibiotics

2018, Fighting Antimicrobial Resistance (IAPC Book)

Leonard Blum, Nadja Tafferner, Ilknur Spring, Jennifer Kurz, Natasja de Bruin, Gerd Geisslinger, Michael J. Parnham, Susanne Schiffmann

Dietary phytol reduces clinical symptoms in experimental autoimmune encephalomyelitis (EAE) at least partially by modulating NOX2 expression.

2018, Journal of Molecular Medicine

Emel Aygören-Pürsün, Anette Bygum, Vesna Grivcheva-Panovska, Markus Magerl, Jochen Graff, Urs C. Steiner, Olivier Fain, Aarnoud Huissoon, Tamar Kinaciyan, Henriette Farkas, Ramon Lleonart, Hilary J. Longhurst, William Rae, Massimo Triggiani, Werner Aberer, Mauro Cancian, Andrea Zanichelli, William B. Smith, Maria L. Baeza, Aurelie Du-Thanh, Mark Gompels, Teresa Gonzalez-Quevedo, Jens Greve, Mar Guilarte, Constance Katelaris, Sylvia Dobo, Melanie Cornpropst, Desiree Clemons, Lei Fang, Phil Collis, William Sheridan, Marcus Maurer, Marco Cicardi

Oral Plasma Kallikrein Inhibitor for Prophylaxis in Hereditary Angioedema.

2018, The New England Journal of Medicine

Michael Rühl, Benjamin Kühn, Jessica Roos, Thorsten Maier, Dieter Steinhilber, Michael Karas

Elucidation of chemical modifier reactivity towards peptides and proteins and the analysis of specific fragmentation by MALDI‐CID‐MS2.

2018, Rapid Communications in Mass Spectrometry

Benjamin Kühn, Camilla Brat, Jasmin Fettel, Nadine Hellmuth, Isabelle Maucher, Ufuk Bulut, Katharina J Hock, Jennifer Grimmer, Georg Manolikakes, Michael Rühl, Alessa Kühn, Kai Zacharowski, Carmela Matrone, Anja Urbschat, Jessica Roos, Dieter Steinhilber, Thorsten Maier

Anti-inflammatory nitro-fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells

2018, Biochemical Pharmacology

Hiromi Shiratori, Carmen Feinweber, Sonja Luckhardt, Nadja Wallner, Gerd Geisslinger, Andreas Weigert, Michael J. Parnham

An in vitro test system for compounds that modulate human inflammatory macrophage polarization

2018, European Journal of Pharmacology

Martine Hofmann, Mike Schmidt, Olga Arne, Gerd Geisslinger, Michael J. Parnham, Natasja de Bruin

Non-invasive bioluminescence imaging as a standardized assessment measure in mouse models of dermal inflammation

2018, Journal of Dermatological Science

Natasja de Bruin, Nerea Ferreiros, Mike Schmidt, Martine Hofmann, Carlo Angioni, Gerd Geisslinger, Michael J. Parnham

Mutual inversion of flurbiprofen enantiomers in various rat and mouse strains

2018, Chirality

Catharina Lippmann, Dario Kringel, Alfred Ultsch, Jörn Lötsch

Computational functional genomics-based approaches in analgesic drug discovery and repurposing

2018, Pharmacogenomics

Christina Mertens, Javier Mora, Bilge Oren, Stephan Grein, Sofia Winslow, Klaus Scholich, Andreas Weigert, Vivianne Malmström, Carina Forsare, Marten Ferno, Tobias Schmid, Bernhard Brüne, Michaela Jung

Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment

2018, Oncoimmunology

Sorin Tunaru, Remy Bonnavion, Isabell Brandenburger, Jens Preussner, Dominique Thomas, Klaus Scholich, Stefan Offermanns

20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1

2018, Nature Communications

Jonas Hausen, Jens C. Otte, Jessica Legradi, Lixin Yang, Uwe Strähle, Martina Fenske, Markus Hecker, Song Tang, Monika Hammers-Wirzt, Henner Hollert, Steffen H. Keiter, Richard Ottermanns

Fishing for contaminants: identification of three mechanism specific transcriptome signatures using Danio rerio embryos

2018, Environmental Science and Pollution Research

Laura Sonnack, Thorsten Klawonn, Ralf Kriehuber, Henner Hollert, Christoph Schäfers, Martina Fenske

Comparative analysis of the transcriptome responses of zebrafish embryos after exposure to low concentrations of cadmium, cobalt and copper

2018, Comparative Biochemistry and Physiology

Mark Wroblewski, Marina Scheller-Wendorff, Raimund Bauer, Florian Udonta, Jara Schlichting, Lin Zhao, Isabel Ben Batalla, Victoria Gensch, Marek Wanior, Hanna Taipaleenmäki, Simona Bolamperti, Zeynab Najafova, Klaus Pantel, Carsten Bokemeyer, Eric Hesse, Stefan Knapp, Steven Johsen, Sonja Loges

BET-Inhibition By JQ1 Promotes Proliferation and Self-Renewal Capacity of Hematopoietic Stem Cells

2018, Haematologica

Daniel K. Glatzel, Andreas Koeberle, Helmut Pein, Konstantin Loeser, Anna Stark, Nelli Keksel, Oliver Werz, Rolf Müller, Iris Bischoff, Robert Fürst

Acetyl-CoA carboxylase 1 regulates endothelial cell migration by shifting the phospholipid composition

2018, The Journal of Lipid Research

Laure Gossec, Dennis McGonagle, Tatiana Korotaeva, Ennio Lubrano, Eugenio de Miguel, Mikkel Ostergaard, Frank Behrens

Minimal Disease Activity as a Treatment Target in Psoriatic Arthritis: A Review of the Literature

2018, The Journal of Rheumatology

Sandra Pierre, Dong Dong Zhang, Jing Suo, Katharina Kern, Neda Tarighi, Klaus Scholich

Myc binding protein 2 suppresses M2-like phenotypes in macrophages during zymosan-induced inflammation in mice

2018, European Journal of Immunology

Andreas Weigert, Andreas von Knethen, Dominik Fuhrmann, Nathalie Dehne, Bernhard Brüne

Redox-signals and macrophage biology (for the upcoming issue of molecular aspects of medicine on signaling by reactive oxygen species)

2018, Molecular Aspects of Medicine

Iris Weyer-Menkhoff, Michael Thrun, Jörn Lötsch

Machine-learned analysis of quantitative sensory testing responses to noxious cold stimulation in healthy subjects

2018, European Journal of Pain

Marthe-Susanna Wegner, Nina Schömel, Lisa Gruber, Stephanie Oertel, Matti Aleksi Kjellberg, Peter Mattjus, Jennifer Kurz, Sandra Trautmann, Bing Peng, Martin Wegner, Manuel Kaulich, Robert Ahrends, Gerd Geisslinger, Sabine Grösch

UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells

2018, Cellular and Molecular Life Sciences

Marthe-Susanna Wegner, Lisa Gruber, Peter Mattjus, Gerd Geisslinger, Sabine Grösch

The UDP-glucose ceramide glycosyltransferase (UGCG) and the link to multidrug resistance protein 1 (MDR1)

2018, BMC Cancer

Dario Kringel, Gerd Geisslinger, Eduard Resch, Bruno Oertel, Michael Thrun, Sarah Heinemann, Jörn Lötsch

Machine-learned analysis of the association of next-generation sequencing-based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin

2018, Pain

Changrong Ge, Dongmei Tong, Bibo Liang, Erik Lonnblom, Nadine Schneider, Cecilia Hagert, Johan Viljanen, Burcu Ayoglu, Roma Stawikowska, Peter Nilsson, Gregg B. Fields, Thomas Skogh, Alf Kastbom, Jan Kihlberg, Harald Burkhardt, Doreen Dobritzsch, Rikard Holmdahl

Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage

2018, JCI Insight

Jörn Lötsch, Alfred Ultsch

Machine learning in pain research

2017, Pain

Michaela Jung, Andreas Weigert, Christina Mertens, Claudia Rehwald, Bernhard Brüne

Iron Handling in Tumor-Associated Macrophages-Is There a New Role for Lipocalin-2?

2017, Frontiers in Immunology

Cheng-Guo Wu, Hui Chen, Feng Guo, Vikash K. Yadav, Sean J. Mcilwain, Michael Rowse, Alka Choudhary, Ziqing Lin, Yitong Li, Tingjia Gu, Aiping Zheng, Qingge Xu, Woojong Lee, Eduard Resch, Benjamin Johnson, Jenny Day, Ying Ge, Irene M. Ong, Mark E. Burkard, Ylva Ivarsson, Yongna Xing

PP2A-B' holoenzyme substrate recognition, regulation and role in cytokinesis

2017, Cell Discovery

Svenja Wiechmann, Anne Gärtner, Andreas Kniss, Andreas Stengl, Christian Behrends, Vladimir V. Rogov, Manuel S. Rodriguez, Volker Dötsch, Stefan Müller, Andreas Ernst

Site-specific inhibition of the small ubiquitin-like modifier (SUMO)-conjugating enzyme Ubc9 selectively impairs SUMO chain formation

2017, The Journal of Biological Chemistry

Sandra Vomund, Anne Schäfer, Michael J. Parnham, Bernhard Brüne, Andreas von Knethen

Nrf2, the Master Regulator of Anti-Oxidative Responses

2017, International Journal of Molecular Sciences

Shahzad Nawaz Syed, Michaela Jung, Andreas Weigert, Bernhard Brüne

S1P Provokes Tumor Lymphangiogenesis via Macrophage-Derived Mediators Such as IL-1beta or Lipocalin-2

2017, Mediators of Inflammation

Laura Sonnack, Thorsten Klawonn, Ralf Kriehuber, Henner Hollert, Christoph Schäfers, Martina Fenske

Concentration dependent transcriptome responses of zebrafish embryos after exposure to cadmium, cobalt and copper

2017, Comparative Biochemistry and Physiology

Bettina Sehnert, Harald Burkhardt, Stephanie Finzel, Stefan Dübel, Reinhard E. Voll

The sneaking ligand approach for cell type-specific modulation of intracellular signalling pathways

2017, Clinical Immunology

Katja Schmitz, Irmgard Tegeder

Bioluminescence and Near-infrared Imaging of Optic Neuritis and Brain Inflammation in the EAE Model of Multiple Sclerosis in Mice

2017, Journal of Visualized Experiments

Fabian Proft, Hendrik Schulze-Koops, Mathias Grünke, Eva Vanessa Schrezenmeier, Fabian Halleck, Jörg Henes, Leonore Unger, Edgar Schmidt, Christoph Fiehn, Annett Jacobi, Christof Iking-Konert, Claudia Kneitz, Reinhold E. Schmidt, Bettina Bannert, Reinhard E. Voll, Rebecca Fischer-Betz, Ina Kötter, Hans-Peter Tony, Julia Holle, Martin Aringer, Anne Erler, Frank Behrens, Gerd Burmester, Thomas Dörner

[Safety and efficacy of off-label use of biologic therapies in patients with inflammatory rheumatic diseases refractory to standard of care therapy : Data from a nationwide German registry (GRAID2)]

2017, Zeitschrift für Rheumatologie

Michael J. Parnham

Progress does not just come in giant leaps: adapting techniques for the study of inflammation to novel applications

2017, Inflammation Research

Catherine Olesch, Christian Ringel, Bernhard Brüne, Andreas Weigert

Beyond Immune Cell Migration: The Emerging Role of the Sphingosine-1-phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell Activation

2017, Mediators of Inflammation

Lutz Menzel, Lisa Kleber, Carina Friedrich, Regina Hummel, Larissa Dangel, Jennifer Winter, Katja Schmitz, Irmgard Tegeder, Michael K. E. Schäfer

Progranulin protects against exaggerated axonal injury and astrogliosis following traumatic brain injury

2017, Glia

Noah Manczyk, Bradley P. Yates, Gianluca Veggiani, Andreas Ernst, Frank Sicheri, Sachdev S. Sidhu

Structural and functional characterization of a ubiquitin variant engineered for tight and specific binding to an alpha-helical ubiquitin interacting motif

2017, Protein Science

Jörn Lötsch, Catharina Lippmann, Dario Kringel, Alfred Ultsch

Integrated Computational Analysis of Genes Associated with Human Hereditary Insensitivity to Pain. A Drug Repurposing Perspective

2017, Frontiers in Molecular Neuroscience

Jörn Lötsch, Alfred Ultsch, Susanne Schiffmann, Irmgard Tegeder, Nerea Ferreiros, Sabine Wicker, Gerd Geisslinger

Machine-learned lipid marker serum concentration based biomarker identifies multiple sclerosis patients at high accuracy

2017, Neurology

Laura Kuchler, Lisa K. Sha, Annika K Giegerich, Tilo Knape, Carlo Angioni, Nerea Ferreiros, Martina V. Schmidt, Andreas Weigert, Bernhard Brüne, Andreas von Knethen

Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis

2017, Molecular Immunology

Dario Kringel, Marco Sisignano, Sebastian Zinn, Jörn Lötsch

Next-generation sequencing of the human TRPV1 gene and the regulating co-players LTB4R and LTB4R2 based on a custom AmpliSeq panel

2017, PLoS One

Michaela Köhm, Frank Behrens

[Psoriatic arthritis : Current therapeutic standards]

2017, Zeitschrift für Rheumatologie

Wiebke Kallenborn-Gerhardt, Christine V. Möser, Jana Lorenz, Micro Steger, Juliana Heidler, Reynir Scheving, Jonas Petersen, Lea Kennel, Cahtrin Flauaus, Ruirui Lu, Aimee L. Edinger, Irmgard Tegeder, Gerd Geisslinger, Heinrich Heide, Ilka Wittig, Achim Schmidtko

Rab7-a novel redox target that modulates inflammatory pain processing

2017, Pain

Michaela Jung, Christina Mertens, Rebekka Bauer, Claudia Rehwald, Bernhard Brüne

Lipocalin-2 and iron trafficking in the tumor microenvironment

2017, Pharmacological Research

Christine Janas, Marc-Philip Mast, Li Kirsamer, Carlo Angioni, Fiona Gao, Werner Mantele, Jennifer Dressman, Matthias G. Wacker

The dispersion releaser technology is an effective method for testing drug release from nanosized drug carriers

2017, European Journal of Pharmaceutics and Biopharmaceutics

Stephan Hohmann, Carlo Angioni, Sorin Tunaru, Seungkyu Lee, Clifford J. Woolf, Stefan Offermanns, Gerd Geisslinger, Klaus Scholich, Marco Sisignano

The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity

2017, Scientific Reports

Dominik Fuhrmann, Bernhard Brüne

Mitochondrial composition and function under the control of hypoxia

2017, Redox Biology

Stefanie Frölich, Patrick Slattery, Dominique Thomas, Itamar Goren, Nerea Ferreiros, Boye L. Jensen, Rolf Nüsing

Angiotensin II-AT1-receptor signaling is necessary for cyclooxygenase-2-dependent postnatal nephron generation

2017, Kidney International

Peter Florian, Peter Wonerow, Sebastian Harder, Karina Kuczka, Michel Dubar, Jochen Graff

Anti-GPVI Fab SAR264565 effectively blocks GPVI function in ex vivo human platelets under arterial shear in a perfusion chamber

2017, European Journal of Clinical Pharmacology

Matthias Englbrecht, Rieke Alten, Martin Aringer, Christoph G. O. Baerwald, Harald Burkhardt, Nancy Eby, Gerhard Fliedner, Bettina Gauger, Ulf Henkemeier, Michael W. Hofmann, Stefan Kleinert, Christian Kneitz, Klaus Krueger, Christof Pohl, Anne-Eve Roske, Georg Schett, Marc Schmalzing, Anne-Kathrin Tausche, Hans-Peter Tony, Joerg Wendler

Validation of Standardized Questionnaires Evaluating Symptoms of Depression in Rheumatoid Arthritis Patients: Approaches to Screening for a Frequent Yet Underrated Challenge

2017, Arthritis Care & Research

Violeta Dimova, Bruno Oertel, Jörn Lötsch

Using a Standardized Clinical Quantitative Sensory Testing Battery to Judge the Clinical Relevance of Sensory Differences Between Adjacent Body Areas

2017, The Clinical Journal of Pain

Ernest Choy, Daniel Aletaha, Frank Behrens, Axel Finckh, Juan Gomez-Reino, Jacques-Eric Gottenberg, Florian Schuch, Andrea Rubbert-Roth

Monotherapy with biologic disease-modifying anti-rheumatic drugs in rheumatoid arthritis

2017, Rheumatology

Xiaofeng Cai, Sarah Nowak, Frank Wesche, Iris Bischoff, Marcel Kaiser, Robert Fürst, Helge B. Bode

Entomopathogenic bacteria use multiple mechanisms for bioactive peptide library design

2017, Nature Chemistry

Dimitra Bogdanou, Marissa Penna-Martinez, Natalie Filmann, T. L. Chung, Yasmin Moran-Auth, J. Wehrle, Claudia Cappel, Sabine Huenecke, Eva Hermann, Ulrike Koehl, Klaus Badenhoop

T-lymphocyte and glycemic status after vitamin D treatment in type 1 diabetes: A randomized controlled trial with sequential crossover

2017, Diabetes/Metabolism Research and Reviews

Christine Bender, Selina Christen, Klaus Scholich, Monika Bayer, Josef Pfeilschifter, Edith Hintermann, Urs Christen

Islet-Expressed CXCL10 Promotes Autoimmune Destruction of Islet Isografts in Mice With Type 1 Diabetes

2017, Diabetes-Journal

Frank Behrens, Diamant Thaci, Jürgen Wollenhaupt, Klaus Krueger

[Psoriatic arthritis : Overview of drug therapy options and administration characteristics]

2017, Hautarzt

Svenja Wiechmann, Andreas Ernst

Engineering von intrazellulären Modulatoren

2017, BIOspektrum

Marissa Penna-Martinez, Klaus Badenhoop

Inherited Variation in Vitamin D Genes and Type 1 Diabetes Predisposition

2017, Genes

Jörn Lötsch, Alfred Ultsch, Eija Kalso

Prediction of persistent post-surgery pain by preoperative cold pain sensitivity: biomarker development with machine-learning-derived analysis

2017, British Journal of Anaesthesia

Nathalie Dehne, Javier Mora, Dmitry Namgaladze, Andreas Weigert, Bernhard Brüne

Cancer cell and macrophage cross-talk in the tumor microenvironment

2017, Current Opinion in Pharmacology

Dafna D. Gladman, William Rigby, Valderilio F. Azevedo, Frank Behrens, Ricardo Blanco, Andrzej Kaszuba, Elizabeth Kudlacz, Cunshan Wang, Sujatha Menon, Thijs Hendrikx, Keith S. Kanik

Tofacitinib for Psoriatic Arthritis in Patients with an Inadequate Response to TNF Inhibitors

2017, The New England Journal of Medicine

Benjamin Weichand, Rudiger Popp, Sarah Dziumbla, Javier Mora, Elisabeth Strack, Eiman Elwakeel, Ann-Christin Frank, Klaus Scholich, Sandra Pierre, Shahzad Nawaz Syed, Catherine Olesch, Julia Ringleb, Bilge Oren, Claudia Döring, Rajkumar Savai, Michaela Jung, Andreas von Knethen, Bodo Levkau, Ingrid Fleming, Andreas Weigert, Bernhard Brüne

S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1beta

2017, Journal of Experimental Medicine

Katja Schmitz, Gerd Geisslinger, Irmgard Tegeder

Monoclonal Antibodies in Preclinical EAE Models of Multiple Sclerosis: A Systematic Review

2017, International Journal of Molecular Sciences

Tanya S. King-Himmelreich, Christine V. Möser, Miriam C. Wolters, Julia Schmetzer, Yannick Schreiber, Nerea Ferreiros, Otto Quintus Russe, Gerd Geisslinger, Ellen Niederberger

AMPK contributes to aerobic exercise-induced antinociception downstream of endocannabinoids

2017, Neuropharmacology

Stephanie Schwalm, Susanne Beyer, Helena Frey, Riad Haceni, Georgios Grammatikos, Dominique Thomas, Gerd Geisslinger, Liliana Schäfer, Andrea Huwiler, Josef Pfeilschifter

Sphingosine kinase-2 deficiency ameliorates kidney fibrosis by up-regulating Smad7 in a mouse model of unilateral ureteral obstruction

2017, The American Journal of Pathology

Stephanie Oertel, Klaus Scholich, Andreas Weigert, Dominique Thomas, Julia Schmetzer, Sandra Trautmann, Marthe-Susanna Wegner, Heinfried H. Radeke, Natalie Filmann, Bernhard Brüne, Gerd Geisslinger, Irmgard Tegeder, Sabine Grösch

Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity

2017, Cellular and Molecular Life Sciences

Bona Linke, Sascha Meyer Dos Santos, Bettina Picard-Willems, Michael Keese, Sebastian Harder, Gerd Geisslinger, Klaus Scholich

CXCL16/CXCR6-mediated adhesion of human peripheral blood mononuclear cells to inflamed endothelium

2017, Cytokine

Jörn Lötsch, Gerd Geisslinger, Sarah Heinemann, Florian Lerch, Bruno Oertel, Alfred Ultsch

Quantitative sensory testing response patterns to capsaicin- and ultraviolet-B-induced local skin hypersensitization in healthy subjects: a machine-learned analysis

2017, Pain

Jörn Lötsch, Michael Thrun, Florian Lerch, Robert Brunkhorst, Susanne Schiffmann, Dominique Thomas, Irmgard Tegeder, Gerd Geisslinger, Alfred Ultsch

Machine-Learned Data Structures of Lipid Marker Serum Concentrations in Multiple Sclerosis Patients Differ from Those in Healthy Subjects.

2017, Internation Journal of Molecular Sciences

Alfred Ultsch, Jörn Lötsch

Machine-learned cluster identification in high-dimensional data

2017, Journal of Biomedical Informatics

Katharina Kern, Sandra Pierre, Yannick Schreiber, Carlo Angioni, Dominique Thomas, Nerea Ferreiros, Gerd Geisslinger, Klaus Scholich

CD200 selectively upregulates prostaglandin E2 and D2 synthesis in LPS-treated bone marrow-derived macrophages

2017, Prostaglandins & Other Lipid Mediators

Katja Schmitz, Robert Brunkhorst, Natasja de Bruin, Christoph Mayer, Annett Haussler, Nerea Ferreiros, Susanne Schiffmann, Michael J. Parnham, Sorin Tunaru, Jerold Chun, Stefan Offermanns, Christian Förch, Klaus Scholich, Johannes Vogt, Sabine Wicker, Jörn Lötsch, Gerd Geisslinger, Irmgard Tegeder

Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis

2017, Acta Neuropathologica Communications

Christian Fork, Andrea E. Vasconez, Patrick Janetzko, Carlo Angioni, Yannick Schreiber, Nerea Ferreiros, Gerd Geisslinger, Matthias S. Leisegang, Dieter Steinhilber, Ralf Brandes

Epigenetic control of microsomal prostaglandin E synthase-1 by HDAC-mediated recruitment of p300

2017, Journal of Lipid Research

Katrin Olbrich, Lara Costard, Christine V. Möser, Katharina Syhr, Tanya S. King-Himmelreich, Miriam C. Wolters, Achim Schmidtko, Gerd Geisslinger, Ellen Niederberger

Cleavage of SNAP-25 ameliorates cancer pain in a mouse model of melanoma

2017, European Journal of Pain

Sabine Grösch, Ellen Niederberger, Gerd Geisslinger

Investigational drugs targeting the prostaglandin E2 signaling pathway for the treatment of inflammatory pain

2017, Expert Opinion on Investigational Drugs

Bona Linke, Yannick Schreiber, Bettina Picard-Willems, Patrick Slattery, Rolf Nüsing, Sebastian Harder, Gerd Geisslinger, Klaus Scholich

Activated Platelets Induce an Anti-Inflammatory Response of Monocytes/Macrophages through Cross-Regulation of PGE2 and Cytokines

2017, Mediators of Inflammation

Tanya S. King-Himmelreich, Christine V. Möser, Miriam C. Wolters, Julia Schmetzer, Moritz Möller, Yannick Schreiber, Nerea Ferreiros, Gerd Geisslinger, Ellen Niederberger

[EXPRESS] AMP-activated kinase and the endogenous endocannabinoid system might contribute to antinociceptive effects of prolonged moderate caloric restriction in mice.

2017, Molecular Pain

Daniel Flesch, Sun-Yee Cheung, Jurema Schmidt, Matthias Gabler, Pascal Heitel, Jan Kramer, Astrid Kaiser, Markus Hartmann, Mara Lindner, Kerstin Lüddens-Dämgen, Jan Heering, Christina Lamers, Hartmut Lüddens, Mario Wurglics, Eugen Proschak, Manfred Schubert-Zsilavecz, Daniel Merk

Nonacidic Farnesoid X Receptor Modulators.

2017, Journal of Medicinal Chemistry

Anna Kraus, Marissa Penna-Martinez, Gisela Meyer, Klaus Badenhoop

Vitamin D effects on monocytes' CCL-2, IL6 and CD14 transcription in Addison's disease and HLA susceptibility.

2017, The Journal of Steroid Biochemistry and Molecular Biology

Katrin Schmidt, Martina Herrero, Sandra Trautmann, Lucija Berninger, Anja Schwiebs, Florian Ottenlinger, Dominique Thomas, Frank Zaucke, Josef Pfeilschifter, Heinfried H. Radeke

Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study

2017, Frontiers in Immunology

Jurema Schmidt, Marco Rotter, Tim Weiser, Sandra K. Wittmann, Lilia Weizel, Astrid Kaiser, Jan Heering, Tamara Göbel, Carlo Angioni, Mario Wurglics, Alexander Paulke, Gerd Geisslinger, Astrid Stefanie Kahnt, Dieter Steinhilber, Eugen Proschak, Daniel Merk

A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis

2017, Journal of Medicinal Chemistry

Christoph Netzer, Tilo Knape, Laura Kuchler, Andreas Weigert, Kai Zacharowski, Waltraud Pfeilschifter, Gregory Sempowski, Michael J. Parnham, Bernhard Brüne, Andreas von Knethen

Apoptotic Diminution of Immature Single and Double Positive Thymocyte Subpopulations Contributes to Thymus Involution During Murine Polymicrobial Sepsis.

2017, Shock

Steffen Uebe, Maria Ehrlicher, Arif B Ekici, Frank Behrens, Beate Bohm, Georg Homuth, Claudia Schurmann, Uwe Völker, Michael Jünger, Heiko Traupe, Michael Krawczak, Harald Burkhardt, André Reis, Ulrike Hüffmeier

Genome-wide association and targeted analysis of copy number variants with psoriatic arthritis in German patients

2017, BMC Medical Genetics

Tatjana Scholz, Andreas Weigert, Bernhard Brüne, Christian David Sadik, Beate Bohm, Harald Burkhardt

GM-CSF in murine psoriasiform dermatitis: Redundant and pathogenic roles uncovered by antibody-induced neutralization and genetic deficiency

2017, PLoS One

Alfred Ultsch, Jörn Lötsch

A data science based standardized Gini index as a Lorenz dominance preserving measure of the inequality of distributions

2017, PLoS One

Leonie Stolz, Amin Derouiche, Kavi Devraj, Frank Weber, Robert Brunkhorst, Christian Förch

Anticoagulation with warfarin and rivaroxaban ameliorates experimental autoimmune encephalomyelitis

2017, Journal of Neuroinflammation

Jessica Roos, Marcus Peters, Isabelle Maucher, Benjamin Kühn, Jasmin Fettel, Nadine Hellmuth, Camilla Brat, Benita Sommer, Anja Urbschat, Matthias Piesche, Anja Vogel, Eugen Proschak, Rene Blöcher, Estel la Buscato, Ann-Kathrin Häfner, Carmela Matrone, Oliver Werz, Juliana Heidler, Bianca M. Wittig, Carlo Angioni, Gerd Geisslinger, Michael J. Parnham, Kai Zacharowski, Dieter Steinhilber, Thorsten Maier

Drug-mediated intracellular donation of nitric oxide potently inhibits 5-lipoxygenase: a possible key to future anti-leukotriene therapy

2017, Antioxidants & redox signaling

Erina Kakumu, Seiya Nakanishi, Hiromi Shiratori, Akari Kato, Wataru Kobayashi, Shinichi Machida, Takeshi Yasuda, Naoko Adachi, Naoaki Saito, Tsuyoshi Ikura, Hitoshi Kurumizaka, Hiroshi Kimura, Masayuki Yokoi, Wataru Sakai, Kaoru Sugasawa

Xeroderma pigmentosum group C protein interacts with histones: regulation by acetylated states of histone H3

2017, Genes to Cells

Hiromi Shiratori, Carmen Feinweber, Sonja Luckhardt, Bona Linke, Eduard Resch, Gerd Geisslinger, Andreas Weigert, Michael J. Parnham

THP-1 and human peripheral blood mononuclear cell-derived macrophages differ in their capacity to polarize in vitro

2017, Molecular Immunology

Ellen Niederberger, Eduard Resch, Michael J. Parnham, Gerd Geisslinger

Drugging the pain epigenome

2017, Nature Reviews Neurology

Eugen Proschak, Pascal Heitel, Lena Kalinowsky, Daniel Merk

Opportunities and Challenges for Fatty Acid Mimetics in Drug Discovery.

2017, Journal of Medicinal Chemistry

Martin F. J. Perescis, Natasja de Bruin, Liesbeth Heijink, Chris Kruse, Lyudmila Vinogradova, Gilles van Luijtelaar, Clementina M. van Rijn

Cannabinoid antagonist SLV326 induces convulsive seizures and changes in the interictal EEG in rats

2017, PLoS One

Sebastian Zinn, Marco Sisignano, Katharina Kern, Sandra Pierre, Sorin Tunaru, Holger Jordan, Jing Suo, Elsa-Marie Treutlein, Carlo Angioni, Nerea Ferreiros, Andreas Leffler, Natasja de Bruin, Stefan Offermanns, Gerd Geisslinger, Klaus Scholich

The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons

2017, The Journal of Biological Chemistry

Isabelle Maucher, Michael Rühl, Simon Kretschmer, Bettina Hofmann, Benjamin Kühn, Jasmin Fettel, Anja Vogel, Karsten T. Flügel, Georg Manolikakes, Nadine Hellmuth, Ann-Kathrin Häfner, Vahid Golghalyani, Ann-Katrin Ball, Matthias Piesche, Carmela Matrone, Gerd Geisslinger, Michael J. Parnham, Michael Karas, Dieter Steinhilber, Jessica Roos, Thorsten Maier

Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418

2017, Biochemical Pharmacology

Katharina J Hock, Jennifer Grimmer, Dominik Göbel, George Gichogo T. Gasaya, Jessica Roos, Isabelle Maucher, Benjamin Kühn, Jasmin Fettel, Thorsten Maier, Georg Manolikakes

Modular Regiospecific Synthesis of Nitrated Fatty Acids

2017, Synthesis

Martin F. J. Perescis, Natasja de Bruin, Liesbeth Heijink, Chris Kruse, Lyudmila Vinogradova, Annika Lüttjohann, Gilles van Luijtelaar, Clementina M. van Rijn

Cannabinoid antagonist SLV326 induces convulsive seizures and changes in the interictal EEG in rats

2017, PLoS One

Christoph Welsch, Mira Efinger, Michael von Wagner, Eva Hermann, Stefan Zeuzem, Tania M. Welzel, Christian Lange

Ongoing liver inflammation in patients with chronic hepatitis C and sustained virological response

2017, PLoS One

Pascal Heitel, Janosch Achenbach, Daniel Moser, Eugen Proschak, Daniel Merk

DrugBank screening revealed alitretinoin and bexarotene as liver X receptor modulators

2017, Bioorganic & Medicinal Chemistry Letters

Tianliang Sun, Lida Yang, Harmandeep Kaur, Jenny Pestel, Mario Looso, Hendrik Nolte, Cornelius Krasel, Daniel Heil, Rameshkumar Krishnan, Marie-Josée Santoni, Jean-Paul Borg, Moritz Bünemann, Stefan Offermanns, Jakub Michal Swiercz, Thomas Worzfeld

A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib

2017, The Journal of Cell Biology

Elsa-Marie Treutlein, Sebastian Zinn, Klaus Scholich

NSAR in the light of fever, inflammation and pain

2017, Pharmakon

Alexandra Stolz, Mateusz Putyrski, Ivana Kutle, Jessica Huber, Chunxin Wang, Viktória Major, Sachdev S. Sidhu, Richard J Youle, Vladimir V. Rogov, Volker Dötsch, Andreas Ernst, Ivan Dikic

Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins

2016, The EMBO Journal

Constanze Schneider, Thomas Oellerich, Hanna-Mari Baldauf, Sarah-Marie Schwarz, Dominique Thomas, Robert Flick, Hanibal Bohnenberger, Lars Kaderali, Lena Stegmann, Anjali Cremer, Margarethe Martin, Julian Lohmeyer, Martin Michaelis, Veit Hornung, Christoph Schliemann, Wolfgang E. Berdel, Wolfgang Hartmann, Eva Wardelmann, Federico Comoglio, Martin-Leo Hansmann, Alexander F. Yakunin, Gerd Geisslinger, Philipp Ströbel, Nerea Ferreiros, Hubert Serve, Oliver T. Keppler, Jindrich Cinatl Jr

SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia

2016, Nature Medicine

Felix Friedländer, Ferdinand Bohmann, Max Brunkhorst, Ju-Hee Chae, Kavi Devraj, Yvette Kohler, Peter Kraft, Hannah Kuhn, Alexandra Lucaciu, Sebastian Luger, Waltraud Pfeilschifter, Rebecca Sadler, Arthur Liesz, Karolina Scholtyschik, Leonie Stolz, Rajkumar Vutukuri, Robert Brunkhorst

Reliability of infarct volumetry: Its relevance and the improvement by a software-assisted approach

2016, Journal of Cerebral Blood Flow & Metabolism

Stefanie Hauck, Kerstin Hiesinger, Sabrina Khageh Hosseini, Janosch Achenbach, Ricardo M. Biondi, Eugen Proschak, Martin Zörnig, Dalibor Odadzic

Pyrazolo[1,5a]pyrimidines as a new class of FUSE binding protein 1 (FUBP1) inhibitors

2016, Bioorganic & Medicinal Chemistry

Sandra Pierre, Bona Linke, Jing Suo, Neda Tarighi, Domenico Del Turco, Dominique Thomas, Nerea Ferreiros, David Stegner, Stefanie Frölich, Marco Sisignano, Laila Romagueira Bichara Dos Santos, Natasja de Bruin, Rolf Nüsing, Thomas Deller, Bernhard Nieswandt, Gerd Geisslinger, Klaus Scholich

GPVI and thromboxane receptor on platelets promote proinflammatory macrophage phenotypes during cutaneous inflammation

2016, Journal of Investigative Dermatology

Josef S. Smolen, Paul Emery, Gianfranco Ferraccioli, Wlodzimierz Samborski, Francis Berenbaum, Owen Davies, Willem Kötse, Oana Purcaru, B. Bennett, Harald Burkhardt

Certolizumab pegol in rheumatoid arthritis patients with low to moderate activity: the CERTAIN double-blind, randomised, placebo-controlled trial

2016, Annals of the rheumatic diseases

Martina Fenske, Elke Muth-Kohne, Vera Delov, Laura Sonnack, Sebastian Kampe, Christoph Schäfers

Detection and validation of molecular biomarkers for neurotoxicity in fish embryos

2016, Neurotoxicology and Teratology

Hiromi Shiratori, Carmen Feinweber, Claudia Knothe, Jörn Lötsch, Dominique Thomas, Gerd Geisslinger, Michael J. Parnham, Eduard Resch

High-Throughput Analysis of Global DNA Methylation Using Methyl-Sensitive Digestion

2016, PloS one

Marco Sisignano, Carlo Angioni, Chul-Kyu Park, Sascha Meyer Dos Santos, Holger Jordan, Maria Kuzikov, Di Liu, Sebastian Zinn, Stephan Hohmann, Yannick Schreiber, Bela Zimmer, Mike Schmidt, Ruirui Lu, Jing Suo, Dong Dong Zhang, Stephan M. G. Schäfer, Martine Hofmann, Ajay S. Yekkirala, Natasja de Bruin, Michael J. Parnham, Clifford J. Woolf, Ru-Rong Ji, Klaus Scholich, Gerd Geisslinger

Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain

2016, Proceedings of the National Academy of Sciences

Sandra K. Wittmann, Lena Kalinowsky, Jan Kramer, Rene Blöcher, Stefan Knapp, Dieter Steinhilber, Denys Pogoryelov, Eugen Proschak, Jan Heering

Thermodynamic properties of leukotriene A4 hydrolase inhibitors

2016, Bioorganic & medicinal chemistry

Katja Zschiebsch, Caroline Fischer, Geethanjali Pickert, Annett Haussler, Heinfried H. Radeke, Sabine Grösch, Nerea Ferreiros, Gerd Geisslinger, Ernst Werner, Irmgard Tegeder

Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling

2016, Journal of Crohn's & colitis

Katharina Syhr, Sebastian Zinn, Gerd Geisslinger

Arzneimittelinteraktionen – „App” to date

2016, Aktuelle Neurologie

Nico Hunzelmann, Gabriela Riemekasten, Markus O. Becker, Pia Moinzadeh, Alexander Kreuter, Inga Melchers, Ulf Müller-Ladner, Florian M. P. Meier, Margitta Worm, Hae-Hyuk Lee, Ilka Herrgott, C. Pfeiffer, Gernhard Fierlbeck, Jörg Henes, Aaron Juche, G. Zeidler, Hartwig Mensing, C. Günther, Miklós Sárdy, Harald Burkhardt, Michaela Köhm, Kathrin Kuhr, Thomas Krieg, Cord Sunderkötter

The Predict Study: low risk for digital ulcer development in patients with systemic sclerosis with increasing disease duration and lack of topoisomerase-1 antibodies

2016, The British journal of dermatology

Marco Brenneis, Ramin Aghajaanpour, Tilo Knape, Lisa Sha, Holger Neb, Patrick Meybohm, Kai Zacharowski, Ingeborg Hauser, Stefan Büttner, Michael J. Parnham, Bernhard Brüne, Andreas von Knethen

Pparγ Expression in T Cells as a Prognostic Marker of Sepsis

2016, Shock

Nicole Mangels, Khader Awwad, Annika Wettenmanna, Laila Romagueira Bichara Dos Santos, Timo Frömel, Ingrid Fleming

The soluble epoxide hydrolase determines cholesterol homeostasis by regulating AMPK and SREBP activity

2016, Prostaglandins & other lipid mediators

Martin Walter Welker, Stefan Luhne, Christian Lange, Johannes Vermehren, Harald Farnik, Eva Hermann, Tania M. Welzel, Stefan Zeuzem, Christoph Sarrazin

Lactic acidosis in patients with hepatitis C virus cirrhosis and combined ribavirin/sofosbuvir treatment

2016, Journal of Hepatology

Andreas Weigert, Javier Mora, Divya Sekar, Shahzad Nawaz Syed, Bernhard Brüne

Killing Is Not Enough: How Apoptosis Hijacks Tumor-Associated Macrophages to Promote Cancer Progression

2016, Advances in Experimental Medicine and Biology

Marthe-Susanna Wegner, Susanne Schiffmann, Michael J. Parnham, Gerd Geisslinger, Sabine Grösch

The enigma of ceramide synthase regulation in mammalian cells

2016, Progress in Lipid Research

Matthias G. Wacker, Ana Proykova, Gustavo Mendes Lima Santos

Dealing with nanosafety around the globe-Regulation vs. innovation

2016, International Journal of Pharmaceutics

Alfred Ultsch, Dario Kringel, Eija Kalso, Jeffrey S. Mogil, Jörn Lötsch

A data science approach to candidate gene selection of pain regarded as a process of learning and neural plasticity

2016, Pain

Michael Tischendorf, Wolfgang Miesbach, Umer Chattah, Zenab Chattah, Sebastian Maier, Christoph Welsch, Stefan Zeuzem, Christian Lange

Differential Kinetics of Coagulation Factors and Natural Anticoagulants in Patients with Liver Cirrhosis: Potential Clinical Implications

2016, PLoS One

Claudia Stross, Tetsuro Shimakami, Katrin Haselow, Monazza Q. Ahmad, Stefan Zeuzem, Christian Lange, Christoph Welsch

Natural HCV variants with increased replicative fitness due to NS3 helicase mutations in the C-terminal helix alpha18

2016, Scientific Reports

Anja Schwiebs, Olga Friesen, Elisabeth Katzy, Nerea Ferreiros, Josef Pfeilschifter, Heinfried H. Radeke

Activation-Induced Cell Death of Dendritic Cells Is Dependent on Sphingosine Kinase 1

2016, Frontiers in Pharmacology

Meike J. Saul, Stefan Stein, Manuel Grez, Per-Johan Jakobsson, Dieter Steinhilber, Beatrix Süß

UPF1 regulates myeloid cell functions and S100A9 expression by the hnRNP E2/miRNA-328 balance

2016, Scientific Reports

Balazs Radnai, Eva M. Sturm, Angela Stancic, Katharina Jandl, Sandra Labocha, Nerea Ferreiros, Magdalena Grill, Carina Hasenoehrl, Gregor Gorkiewicz, Gunther Marsche, Akos Heinemann, Christoph Hogenauer, Rudolf Schicho

Eosinophils Contribute to Intestinal Inflammation via Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells, CRTH2, in Experimental Crohn's Disease

2016, Journal of Crohn's and Colitis

Alexander Paulke, Eugen Proschak, Kai Sommer, Janosch Achenbach, Cora Wunder, Stefan W. Toennes

Synthetic cannabinoids: In silico prediction of the cannabinoid receptor 1 affinity by a quantitative structure-activity relationship model

2016, Toxicology Letters

Bilge Oren, Jelena Urosevic, Christina Mertens, Javier Mora, Marc Guiu, Roger R. Gomis, Andreas Weigert, Thomas Schmid, Stephan Grein, Bernhard Brüne, Michaela Jung

Tumour stroma-derived lipocalin-2 promotes breast cancer metastasis

2016, The Journal of Pathology

Elke Muth-Kohne, Kathi Westphal-Settele, Jasmin Bruckner, Sabine Konradi, Viktoria Schiller, Christoph Schäfers, Matthias Teigeler, Martina Fenske

Linking the response of endocrine regulated genes to adverse effects on sex differentiation improves comprehension of aromatase inhibition in a Fish Sexual Development Test

2016, Aquatic Toxicology

Javier Mora, Andreas Weigert

IL-1 family cytokines in cancer immunity - a matter of life and death

2016, Biological Chemistry

Javier Mora, Andrea Schlemmer, Ilka Wittig, Florian Richter, Mateusz Putyrski, Ann-Christin Frank, Yingying Han, Michaela Jung, Andreas Ernst, Andreas Weigert, Bernhard Brüne

Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses

2016, Journal of Molecular Cell Biology

Jochen Moll, Sascha Meyer Dos Santos, Bernd Hils, Fabian Dornuf, Isabel Rodrigues Meyer dos Santos, Oliver C. Singer, Nerea Ferreiros, Sandra Labocha, Annemarie Blucher, Sebastian Harder, Viktor Krozer

Micro-optical prototyping of a surface acoustic wave-based point-of-care coagulation assay and first application in anticoagulated patients

2016, Int. Journal of Clinical Pharmacology and Therapeutics

Karin Meirer, Daniel K. Glatzel, Simon Kretschmer, Sandra K. Wittmann, Markus Hartmann, Rene Blöcher, Carlo Angioni, Gerd Geisslinger, Dieter Steinhilber, Bettina Hofmann, Robert Fürst, Eugen Proschak

Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase

2016, Molecules

Timurs Maculins, Evgenij Fiskin, Sagar Bhogaraju, Ivan Dikic

Bacteria-host relationship: ubiquitin ligases as weapons of invasion

2016, Cell Research

Timurs Maculins, Nikki Carter, Thierry Dorval, Kevin Hudson, J. Willem M. Nissink, Ronald T. Hay, Husam Alwan

A Generic Platform for Cellular Screening Against Ubiquitin Ligases

2016, Scientific Reports

Jörn Lötsch, Alfred Ultsch, Thomas Hummel

How Many and Which Odor Identification Items Are Needed to Establish Normal Olfactory Function?

2016, Chemical Senses

Jörn Lötsch, Alfred Ultsch, Thomas Hummel

A Unifying Data-Driven Model of Human Olfactory Pathology Representing Known Etiologies of Dysfunction

2016, Chemical Senses

Jörn Lötsch, Alfred Ultsch, Maren Eckhardt, Caroline Huart, Philippe Rombaux, Thomas Hummel

Brain lesion-pattern analysis in patients with olfactory dysfunctions following head trauma

2016, NeuroImage: Clinical

Jörn Lötsch, Alfred Ultsch

Process Pharmacology: A Pharmacological Data Science Approach to Drug Development and Therapy

2016, CPT: Pharmacometrics & Systems Pharmacology

Jörn Lötsch, Thomas Hummel, Alfred Ultsch

Machine-learned pattern identification in olfactory subtest results

2016, Scientific Reports

Jörn Lötsch, Antje Hahner, Gudrun Gossrau, Cornelia Hummel, Carmen Walter, Alfred Ultsch, Thomas Hummel

Smell of pain: intersection of nociception and olfaction

2016, Pain

Dario Kringel, Jörn Lötsch

Next-generation sequencing of human opioid receptor genes based on a custom AmpliSeq library and ion torrent personal genome machine

2016, Clinica Chimica Acta

Franca-Maria Klingler, Markus Wolf, Sandra K. Wittmann, Philipp Gribbon, Eugen Proschak

Bacterial Expression and HTS Assessment of Soluble Epoxide Hydrolase Phosphatase

2016, Journal of Biomolecular Screening

Marina Kemmerer, Ilka Wittig, Florian Richter, Bernhard Brüne, Dmitry Namgaladze

AMPK activates LXRalpha and ABCA1 expression in human macrophages

2016, The International Journal of Biochemistry & Cell Biology

Michaela Jung, Bilge Oren, Javier Mora, Christina Mertens, Sarah Dziumbla, Rudiger Popp, Andreas Weigert, Nina Grossmann, Ingrid Fleming, Bernhard Brüne

Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis

2016, Science Signaling

Ivana Josipovic, Christian Fork, Jens Preussner, Dijana Iloska, Andrea E. Vasconez, Sandra Labocha, Carlo Angioni, Dominique Thomas, Nerea Ferreiros, Mario Looso, Soni S. Pullamsetti, Gerd Geisslinger, Dieter Steinhilber, Ralf Brandes, Matthias S. Leisegang

PAFAH1B1 and the lncRNA NONHSAT073641 maintain an angiogenic phenotype in human endothelial cells

2016, Acta Physiologica

Christine Janas, Zouhair Mostaphoui, Johann Bauer, Matthias G. Wacker

Novel polymeric micelles for drug delivery: Material characterization and formulation screening

2016, International Journal of Pharmaceutics

Nina Henke, Nerea Ferreiros, Gerd Geisslinger, Martina G. Ding, Silke Essler, Dominik Fuhrmann, Theresa Geis, Dmitry Namgaladze, Nathalie Dehne, Bernhard Brüne

Loss of HIF-1alpha in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model

2016, Oncotarget

Ann-Kathrin Häfner, Kim Beilstein, Philipp Graab, Ann-Katrin Ball, Meike J. Saul, Bettina Hofmann, Dieter Steinhilber

Identification and Characterization of a New Protein Isoform of Human 5-Lipoxygenase

2016, PLoS One

Georgios Grammatikos, Julia Dietz, Nerea Ferreiros, Alexander Koch, Georg Dultz, Dimitra Bon, Ioannis Karakasiliotis, Thomas Lutz, Gaby Knecht, Peter Gute, Eva Hermann, Stefan Zeuzem, Penelope Mavromara, Christoph Sarrazin, Josef Pfeilschifter

Persistence of HCV in Acutely-Infected Patients Depletes C24-Ceramide and Upregulates Sphingosine and Sphinganine Serum Levels

2016, International Journal of Molecular Sciences

Jochen Graff, Ernst-Heinrich Scheuermann, Gunnar Brandhorst, Michael Oellerich, Jan Gossmann

Pharmacokinetic Analysis of Mycophenolate Mofetil and Enteric-Coated Mycophenolate Sodium in Calcineurin Inhibitor-Free Renal Transplant Recipients

2016, Therapeutic Drug Monitoring

Robert Fürst

Narciclasine - an Amaryllidaceae Alkaloid with Potent Antitumor and Anti-Inflammatory Properties

2016, Planta Medica

Simone Fuchs, Iris Bischoff, Elisabeth A. Willer, Jacqueline Brautigam, Martin F. Bubik, Clemens Erdelmeier, Egon Koch, Maria T. Faleschini, Maria De Mieri, Milena Bauhart, Stefan Zahler, Andreas Hensel, Matthias Hamburger, Oliver Potterat, Robert Fürst

The Dual Edema-Preventing Molecular Mechanism of the Crataegus Extract WS 1442 Can Be Assigned to Distinct Phytochemical Fractions

2016, Planta Medica

Martina Fenske, Sheraz Gul

Zebrafish early-life stages as neurological screening and detection tools

2016, Drug Target Review

Natasja de Bruin, Arnold van Loevezijn, Karsten Wicke, Martin de Haan, Jennifer Venhorst, Jos Lange, Lotte de Groote, Martine van der Neut, Jos Prickaerts, Emile Andriambeloson, Andrew Foley, Martin van Drimmelen, Marieke van de Wetering, C. G. Kruse

The selective 5-HT6 receptor antagonist SLV has putative cognitive- and social interaction enhancing properties in rodent models of cognitive impairment

2016, Neurobiology of Learning and Memory

Ricardo Capelo, Christoph Lehmann, Khalil Ahmad, Ryan Snodgrass, Olaf Diehl, Julia Ringleb, Nicolas Flamand, Andreas Weigert, Holger Stark, Dieter Steinhilber, Astrid Stefanie Kahnt

Cellular analysis of the histamine H4 receptor in human myeloid cells

2016, Biochemical Pharmacology

Harald Burkhardt, Peter Weisenseel, Marc Alexander Radtke, Klaus Krueger

[Malignancies of the skin and immunomodulatory antirheumatic therapy]

2016, Zeitschrift für Rheumatologie

Bernhard Brüne, Nadine Courtial, Nathalie Dehne, Shahzad Nawaz Syed, Andreas Weigert

Macrophage NOS2 in Tumor Leukocytes

2016, Antioxidants & Redox Signaling

Marcel Boss, Yvette Newbatt, Sahil Gupta, Ian Collins, Bernhard Brüne, Dmitry Namgaladze

AMPK-independent inhibition of human macrophage ER stress response by AICAR

2016, Scientific Reports

Lambert Bodewein, Frank Schmelter, Stefano Di Fiore, Henner Hollert, Rainer Fischer, Martina Fenske

Differences in toxicity of anionic and cationic PAMAM and PPI dendrimers in zebrafish embryos and cancer cell lines

2016, Toxicology and Applied Pharmacology

Rene Blöcher, Christina Lamers, Sandra K. Wittmann, Olaf Diehl, Thomas Hanke, Daniel Merk, Dieter Steinhilber, Manfred Schubert-Zsilavecz, Astrid Stefanie Kahnt, Eugen Proschak

Design and synthesis of fused soluble epoxide hydrolase/peroxisome proliferator-activated receptor modulators

2016, MedChemComm

Iris Bischoff, Michael C. Hornburger, Bettina A. Mayer, Andrea Beyerle, Joachim Wegener, Robert Fürst

Pitfalls in assessing microvascular endothelial barrier function: impedance-based devices versus the classic macromolecular tracer assay

2016, Scientific Reports

Susanne Beyer, Li Xie, Mike Schmidt, Natasja de Bruin, Mukul Ashtikar, Sabrina Ruschenbaum, Christian Lange, Vitali Vogel, Werner Mantele, Michael J. Parnham, Matthias G. Wacker

Optimizing novel implant formulations for the prolonged release of biopharmaceuticals using in vitro and in vivo imaging techniques

2016, Journal of Controlled Release

Frank Behrens, Michaela Köhm, Diamant Thaci, Holger Gnann, Gerg Greger, Bianca M. Wittig, Harald Burkhardt

Anti-citrullinated protein antibodies are linked to erosive disease in an observational study of patients with psoriatic arthritis

2016, Rheumatology

Christine Altmann, Verica Vasic, Stefanie Hardt, Juliana Heidler, Annett Haussler, Ilka Wittig, Mirko H. H. Schmidt, Irmgard Tegeder

Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling

2016, Molecular Neurodegeneration

Christine Altmann, Stefanie Hardt, Caroline Fischer, Juliana Heidler, Hee-Young Lim, Annett Haussler, Boris Albuquerque, Bela Zimmer, Christine V. Möser, Christian Behrends, Frank Koentgen, Ilka Wittig, Mirko H. H. Schmidt, Albrecht M. Clement, Thomas Deller, Irmgard Tegeder

Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy

2016, Neurobiology of Disease

Julia Barthelmes, Nadja Tafferner, Jennifer Kurz, Natasja de Bruin, Michael J. Parnham, Gerd Geisslinger, Susanne Schiffmann

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

2016, Journal of visualized experiments

Peter Müller, Marie Messmer, Monika Bayer, Josef Pfeilschifter, Edith Hintermann, Urs Christen

Non-alcoholic fatty liver disease (NAFLD) potentiates autoimmune hepatitis in the CYP2D6 mouse model

2016, Journal of autoimmunity

Tanya S. King-Himmelreich, Stefanie Schramm, Miriam C. Wolters, Julia Schmetzer, Christine V. Möser, Claudia Knothe, Eduard Resch, Johannes Peil, Gerd Geisslinger, Ellen Niederberger

The impact of endurance exercise on global and AMPK gene-specific DNA methylation

2016

Claudia Knothe, Hiromi Shiratori, Eduard Resch, Alfred Ultsch, Gerd Geisslinger, Alexandra Doehring, Jörn Lötsch

Disagreement between two common biomarkers of global DNA methylation

2016, Clinical epigenetics

Dario Kringel, Alfred Ultsch, Michael Zimmermann, Jan Peter Jansen, Wilfried Ilias, Rainer Freynhagen, Norbert Griessinger, Dr. Andreas Kopf, Christoph Stein, Alexandra Doehring, Eduard Resch, Jörn Lötsch

Emergent biomarker derived from next-generation sequencing to identify pain patients requiring uncommonly high opioid doses

2016, The pharmacogenomics journal

Carmen Walter, Bruno Oertel, Lisa Felden, Christian A. Kell, Ulrike Noth, Johannes Vermehren, Jochen Kaiser, Ralf Deichmann, Jörn Lötsch

Brain Mapping-Based Model of Delta(9)-Tetrahydrocannabinol Effects on Connectivity in the Pain Matrix

2016, Neuropsychopharmacology

Alfred Ultsch, Michael Thrun, Onno Hansen-Goos, Jörn Lötsch

Identification of Molecular Fingerprints in Human Heat Pain Thresholds by Use of an Interactive Mixture Model R Toolbox

2016, International journal of molecular sciences

Marcel Boss, Marina Kemmerer, Bernhard Brüne, Dmitry Namgaladze

FABP4 inhibition suppresses PPARgamma activity and VLDL-induced foam cell formation in IL-4-polarized human macrophages

2016, Atherosclerosis

Christine V. Möser, Markus Meissner, Kathrin Laarmann, Katrin Olbrich, Tanya S. King-Himmelreich, Miriam C. Wolters, Gerd Geisslinger, Ellen Niederberger

The protein kinase IKKepsilon contributes to tumour growth and tumour pain in a melanoma model

2016, Biochemical pharmacology

Natasja de Bruin, Katja Schmitz, Susanne Schiffmann, Nadja Tafferner, Mike Schmidt, Holger Jordan, Annett Haussler, Irmgard Tegeder, Gerd Geisslinger, Michael J. Parnham

Multiple rodent models and behavioral measures reveal unexpected responses to FTY720 and DMF in experimental autoimmune encephalomyelitis

2016, Behavioural brain research

Marco Sisignano, Michael J. Parnham, Gerd Geisslinger

Drug Repurposing for the Development of Novel Analgesics

2016, Trends in pharmacological sciences

Frank Behrens, Michaela Köhm, Uta Arndt, Gerg Greger, Diamant Thaci, Eva C Scharbatke, Hans-Peter Tony, Harald Burkhardt

Does Concomitant Methotrexate with Adalimumab Influence Treatment Outcomes in Patients with Psoriatic Arthritis? Data from a Large Observational Study

2016, The Journal of Rheumatology

Christina Dillmann, Christian Ringel, Julia Ringleb, Javier Mora, Catherine Olesch, Annika Fink, Edward Roberts, Bernhard Brüne, Andreas Weigert

S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-α Production by Human Plasmacytoid Dendritic Cells

2016, Journal of immunology

Claudia Knothe, Bruno Oertel, Alfred Ultsch, Mattias Kettner, Peter Harald Schmidt, Cora Wunder, Stefan W. Toennes, Gerd Geisslinger, Jörn Lötsch

Pharmacoepigenetics of the Role of DNA Methylation in μ-Opioid Receptor Expression in Different Human Brain Regions

2016, Epigenomics

Simon Kretschmer, Stefano Woltersdorf, Dominik Vogt, Felix F. Lillich, Michael Rühl, Michael Karas, Isabelle Maucher, Jessica Roos, Ann-Kathrin Häfner, Astrid Kaiser, Mario Wurglics, Manfred Schubert-Zsilavecz, Carlo Angioni, Gerd Geisslinger, Holger Stark, Dieter Steinhilber, Bettina Hofmann

Characterization of the molecular mechanism of 5-lipoxygenase inhibition by 2-aminothiazoles

2016, Biochemical Pharmacology

Vassilios Myrianthopoulos, Nicolas Gaboriaud-Kolar, Cynthia Tallant, Michelle-Lynn Hall, Stylianos Grigoriou, Peter Moore Brownlee, Oleg Fedorov, Catherine Rogers, David Heidenreich, Marek Wanior, Nikolaos Drosos, Nikitia Mexia, Tina Bagratuni, Efstathios Kastritis, Evangelos Terpos, Panagis Filippakopoulos, Susanne Müller, Alexios-Leandros Skaltsounis, Jessica Ann Downs, Stefan Knapp, Emmanuel Mikros

Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis

2016, Journal of Medicinal Chemistry

Florian Ottenlinger, Christoph Mayer, Nerea Ferreiros, Yannick Schreiber, Anja Schwiebs, Katrin Schmidt, Hanns Ackermann, Josef Pfeilschifter, Heinfried H. Radeke

Interferon-Beta Increases Plasma Ceramides of Specific Chain Length in Multiple Sclerosis Patients, Unlike Fingolimod or Natalizumab

2016, Frontiers in Pharmacology

Jessica Roos, Benjamin Kühn, Jasmin Fettel, Isabelle Maucher, Martin Ruthard, Astrid Stefanie Kahnt, Thomas Vorup-Jensen, Carmela Matrone, Dieter Steinhilber, Thorsten Maier

Role of Lipoxygenases in Pathogenesis of Cancer

2016, Progress in Inflammation Research

Claudia Knothe, Alexandra Doehring, Alfred Ultsch, Jörn Lötsch

Methadone induces hypermethylation of human DNA

2016, Epigenomics

Simon Kretschmer, Stefano Woltersdorf, Carmen B. Rödl, Dominik Vogt, Ann-Kathrin Häfner, Dieter Steinhilber, Holger Stark, Bettina Hofmann

Development of novel aminothiazole-comprising 5-LO inhibitors

2016, Future medicinal chemistry

Anika Berner, Malte Bachmann, Christine Bender, Josef Pfeilschifter, Urs Christen, Heiko Mühl

Though Active on RINm5F Insulinoma Cells and Cultured Pancreatic Islets, Recombinant IL-22 Fails to Modulate Cytotoxicity and Disease in a Protocol of Streptozotocin-Induced Experimental Diabetes

2016, Frontiers in pharmacology

Nadja Tafferner, Julia Barthelmes, Max Eberle, Thomas Ulshöfer, Marina Henke, Natasja de Bruin, Christoph Mayer, Christian Förch, Gerd Geisslinger, Michael J. Parnham, Susanne Schiffmann

Alpha-methylacyl-CoA racemase deletion has mutually counteracting effects on T-cell responses, associated with unchanged course of EAE

2016, European journal of immunology

Rene Blöcher, Christina Lamers, Sandra K. Wittmann, Daniel Merk, Markus Hartmann, Lilia Weizel, Olaf Diehl, Astrid Brüggerhoff, Marcel Boss, Astrid Kaiser, Tim Schader, Tamara Göbel, Manuel Grundmann, Carlo Angioni, Jan Heering, Gerd Geisslinger, Mario Wurglics, Evi Kostenis, Bernhard Brüne, Dieter Steinhilber, Manfred Schubert-Zsilavecz, Astrid Stefanie Kahnt, Eugen Proschak

N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators

2016, Journal of medicinal chemistry

Carmen Walter, Claudia Knothe, Jörn Lötsch

Abuse-Deterrent Opioid Formulations: Pharmacokinetic and Pharmacodynamic Considerations

2016, Clinical pharmacokinetics

Jessica Roos, Sabine Grösch, Oliver Werz, Peter Schröder, Slava Ziegler, Simone Fulda, Patrick Paulus, Anja Urbschat, Benjamin Kühn, Isabelle Maucher, Jasmin Fettel, Thomas Vorup-Jensen, Matthias Piesche, Carmela Matrone, Dieter Steinhilber, Michael J. Parnham, Thorsten Maier

Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?

2016, Pharmacology & therapeutics

Christian Grimm, Denise Tischner, Kerstin Troidl, Julián Albarrán Juárez, Kishor Kumar Sivaraj, Nerea Ferreiros, Gerd Geisslinger, Christoph J. Binder, Nina Wettschureck

S1P2/G12/13 Signaling Negatively Regulates Macrophage Activation and Indirectly Shapes the Atheroprotective B1-Cell Population

2016, Arteriosclerosis, thrombosis, and vascular biology

Thomas Hanke, Daniel Merk, Dieter Steinhilber, Gerd Geisslinger, Manfred Schubert-Zsilavecz

Small molecules with anti-inflammatory properties in clinical development

2016, Pharmacology & therapeutics

Jörn Lötsch, Alfred Ultsch

A computational functional genomics based self-limiting self-concentration mechanism of cell specialization as a biological role of jumping genes

2016, Integrative biology : quantitative biosciences from nano to macro

Christoph Lehmann, Julia Homann, Ann-Katrin Ball, Rene Blöcher, Thea K Kleinschmidt, Devaraj Basavarajappa, Nerea Ferreiros, Ann-Kathrin Häfner, Olof Radmark, Jesper Z. Haeggstrom, Gerd Geisslinger, Michael J. Parnham, Dieter Steinhilber, Astrid Stefanie Kahnt

Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein

2015, FASEB Journal

Florian Ottenlinger, Anja Schwiebs, Kathrin Pfarr, Sophia Gruner, Christoph Mayer, Josef Pfeilschifter, Heinfried H. Radeke

Fingolimod targeting protein phosphatase 2A differently affects IL-33 induced IL-2 and IFN-gamma production in CD8 lymphocytes

2015, European journal of immunology

Violeta Dimova, Jörn Lötsch, Kathrin Hühne, Andreas Winterpacht, Michael Heesen, Andreas Parthum, Peter G. Weber, Roman Carbon, Norbert Griessinger, Reinhard Sittl

Association of genetic and psychological factors with persistent pain after cosmetic thoracic surgery

2015, Journal of pain research

Johannes Vogt, Jenq-Wei Yang, Arian Mosbascher, Jin Cheng, Yunbo Li, Xingfeng Liu, Jan Baumgart, Carine Thalman, Sergei Kirischuk, Petri Unichenko, Guillherme Horta, Konstantin Radyushkin, Albrecht Stroh, Sebastian Richers, Nassim Sahragard, Ute Distler, Stefan Tenzer, Lianyong Qiao, Klaus Lieb, Oliver Tüscher, Harald Binder, Nerea Ferreiros, Irmgard Tegeder, Andrew J. Morris, Sergiu Gropa, Peter Nürnberg, Mohammad R. Toliat, Georg Winterer, Heiko J. Luhmann, Jisen Huai, Robert Nitsch

Molecular cause and functional impact of altered synaptic lipid signaling due to a prg-1 gene SNP

2015, EMBO molecular medicine

Stanley Lasch, Peter Müller, Monika Bayer, Josef Pfeilschifter, Andrew D. Luster, Edith Hintermann, Urs Christen

Anti-CD3/Anti-CXCL10 Antibody Combination Therapy Induces a Persistent Remission of Type 1 Diabetes in Two Mouse Models

2015, Diabetes

Jörn Lötsch, Nicole Reither, Vasyl Bogdanov, Antje Hahner, Alfred Ultsch, K Hill, Thomas Hummel

A brain-lesion pattern based algorithm for the diagnosis of posttraumatic olfactory loss

2015, Rhinology

Tanya S. King-Himmelreich, Christine V. Möser, Miriam C. Wolters, Katrin Olbrich, Gerd Geisslinger, Ellen Niederberger

Age-Dependent Changes in the Inflammatory Nociceptive Behavior of Mice

2015, International journal of molecular sciences

Jörn Lötsch, Claudia Knothe, Catharina Lippmann, Alfred Ultsch, Thomas Hummel, Carmen Walter

Olfactory drug effects approached from human-derived data

2015, Drug discovery today

Ryan Snodgrass, Marcel Boss, Ekaterina Zezina, Andreas Weigert, Nathalie Dehne, Ingrid Fleming, Bernhard Brüne, Dmitry Namgaladze

Hypoxia Potentiates Palmitate-induced Pro-inflammatory Activation of Primary Human Macrophages

2015, The Journal of biological chemistry

Carla Jennewein, Ralf Sowa, Anne C Faber, Madlen Dildey, Andreas von Knethen, Patrick Meybohm, Bertram Scheller, Stefan Dröse, Kai Zacharowski

Contribution of Ninjurin1 to Toll-like receptor 4 signaling and systemic inflammation

2015, American journal of respiratory cell and molecular biology

Franca-Maria Klingler, Daniel Moser, Dominik Büttner, Thomas A. Wichelhaus, Dr. Frank Lohr, Volker Dötsch, Eugen Proschak

Probing metallo-beta-lactamases with molecular fragments identified by consensus docking

2015, Bioorganic & medicinal chemistry letters

Ellen Niederberger, Tanya S. King-Himmelreich, Otto Quintus Russe, Gerd Geisslinger

Activation of AMPK and its Impact on Exercise Capacity

2015, Sports medicine

Jean-Louis Vincent, David Brealey, Nicolas Libert, Kai Zacharowski, Malgorzata Mikaszewska-Sokolewicz, Jacques Schrenzel, Francois Simon, Mark Wilks, Marcus Picard-Maureau, Donald B. Chalfin, David J. Ecker, Rangarajan Sampath, Mervyn Singer

Rapid Diagnosis of Infection in the Critically Ill, a Multicenter Study of Molecular Detection in Bloodstream Infections, Pneumonia, and Sterile Site Infections

2015, Critical care medicine

Angelika F. Winkel, Christian K. Engel, Daniel Margerie, Aimo Kannt, hauke Szillat, Heiner Glombik, Christopher Kallus, Sven Ruf, Stefan Güssregen, Jens Riedel, Andreas W. Herling, Andreas von Knethen, Andreas Weigert, Bernhard Brüne, Dieter Schmoll

Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling

2015, The Journal of biological chemistry

Julia Homann, Jing Suo, Mike Schmidt, Natasja de Bruin, Klaus Scholich, Gerd Geisslinger, Nerea Ferreiros

In Vivo Availability of Pro-Resolving Lipid Mediators in Oxazolone Induced Dermal Inflammation in the Mouse

2015, PloS one

Jörn Lötsch, Ellen Niederberger, Alfred Ultsch

Computational functional genomics based analysis of pain-relevant micro-RNAs

2015, Human genetics

Michael Hogardt, Timo Wolf, Gerrit Kann, Hans-Reinhard Brodt, Christian Brandt, Oliver T. Keppler, Sabine Wicker, Kai Zacharowski, René Gottschalk, Stephan Becker, Volkhard Kempf

Management of Microbiological Samples in a Confirmed Case of Ebola Virus Disease: Constraints and Limitations

2015, Journal of clinical microbiology

Jörn Lötsch, Violeta Dimova, Alfred Ultsch, Isabel Lieb, Michael Zimmermann, Gerd Geisslinger, Bruno Oertel

A small yet comprehensive subset of human experimental pain models emerging from correlation analysis with a clinical quantitative sensory testing protocol in healthy subjects

2015, European Journal of Pain

Harald Farnik, Tim Zimmermann, Eva Hermann, Wolf Bechstein, Bernd Kronenberger, Peter R. Galle, Sandra Labocha, Nerea Ferreiros, Gerd Geisslinger, Stefan Zeuzem, Christoph Sarrazin, Martin Walter Welker

Telaprevir drug monitoring during antiviral therapy of hepatitis C graft infection after liver transplantation

2015, Liver international

Khader Awwad, Lei Shi, Nicole Mangels, Randa Abdel Malik, Nina Zippel, Beate Fisslthaler, Johannes A. Eble, Josef Pfeilschifter, Rudiger Popp, Ingrid Fleming

Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor beta signalling and angiogenesis

2015, Cardiovascular research

Rotraut Mössner, Yvonne Frambach, Dagma Wilsmann-Theis, Sabine Löhr, Arnd Jacobi, Ansgar Weyergraf, Michael Müller, Sandra Philipp, Regina Renner, Heiko Traupe, Harald Burkhardt, Külli Kingo, Sulev Koks, Steffen Uebe, Michael Sticherling, Heinrich Sticht, Vinzenz Oji, Ulrike Hüffmeier

Palmoplantar Pustular Psoriasis Is Associated with Missense Variants in CARD14, but Not with Loss-of-Function Mutations in IL36RN in European Patients

2015, The Journal of investigative dermatology

Dmitry Namgaladze, Ryan Snodgrass, Carlo Angioni, Nina Grossmann, Nathalie Dehne, Gerd Geisslinger, Bernhard Brüne

AMP-activated protein kinase suppresses arachidonate 15-lipoxygenase expression in interleukin 4-polarized human macrophages

2015, The Journal of biological chemistry

Ellen Niederberger, Rohini Kuner, Gerd Geisslinger

Pharmacological aspects of pain research in Germany

2015, Schmerz

Jurema Schmidt, Franca-Maria Klingler, Eugen Proschak, Dieter Steinhilber, Manfred Schubert-Zsilavecz, Daniel Merk

NSAIDs Ibuprofen, Indometacin, and Diclofenac do not interact with Farnesoid X Receptor

2015, Scientific reports

John Bowes, Sabine Löhr, Ashley Budu-Aggrey, Steffen Uebe, Ian N Bruce, Marie Feletar, Helena Marzo-Ortega, Philip S. Helliwell, Anthony W. Ryan, David Kane, Eleanor Korendowych, Gerd-Marie Alenius, Emiliano Giardiana, Jon Packham, Ross McManus, Oliver Fitzgerald, Matthew A. Brown, Frank Behrens, Harald Burkhardt, Neil McHugh, Ulrike Hüffmeier, Pauline Ho, André Reis, Anne Barton

PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus

2015, Annals of the rheumatic diseases

Marcel Flemming, Birgit Kraus, Anne Rascle, Guido Jürgenliemk, Simone Fuchs, Robert Fürst, Jörg Heilmann

Revisited anti-inflammatory activity of matricine in vitro: Comparison with chamazulene

2015, Fitoterapia

Daniel Flesch, Manfred Schubert-Zsilavecz

Synthesis of imidazo[1,2-a]pyridines in a sequential one-pot Groebke-Blackburn modification using 2-aminopyridines, aldehydes and amines

2015, Die Pharmazie

Khalil Ahmad, Bastian Scholz, Ricardo Capelo, Ilona Schweighofer, Astrid Stefanie Kahnt, Rolf Marschalek, Dieter Steinhilber

AF4 and AF4-MLL mediate transcriptional elongation of 5-lipoxygenase mRNA by 1, 25-dihydroxyvitamin D3

2015, Oncotarget

Anja Urbschat, Katrin Rupprecht, Kai Zacharowski, Nicholas Obermüller, Bertram Scheller, Johannes Holfeld, Can Tepeköylü, Rainer Hofmann, Patrick Paulus

Combined peri-ischemic administration of Bbeta15-42 in treating ischemia reperfusion injury of the mouse kidney

2015, Microvascular research

Michaela Köhm, Harald Burkhardt, Frank Behrens

Anti-TNFalpha-therapy as an evidence-based treatment option for different clinical manifestations of psoriatic arthritis

2015, Clinical and experimental rheumatology

Christoph Mayer, Anika Männer de Bazo, Christian Förch, Max Eberle, Philipp Ebel, Julia Barthelmes, Nadja Tafferner, Nerea Ferreiros, Thomas Ulshöfer, Marina Henke, Sabine Grösch, Gerd Geisslinger, Klaus Willecke, Susanne Schiffmann

Ceramide synthase6 / C16-ceramides mediate anti-inflammatory effects during the development of EAE and MS possibly by suppressing the migration and by deactivation of neutrophils: a new target for anti-inflammatory therapy in MS?

2015, Multiple Sclerosis Journal

Christoph Mayer, Nadja Tafferner, Julia Barthelmes, Max Eberle, Nerea Ferreiros, Thomas Ulshöfer, Marina Henke, Natasja de Bruin, Gerd Geisslinger, Christian Förch, Michael J. Parnham, Susanne Schiffmann

Different pathophysiological relevance of branched fatty acid metabolism in mice and men: alpha-methylacyl-CoA racemase regulates the T cell response only in experimental autoimmune encephalomyelitis but not in multiple sclerosis

2015, Multiple Sclerosis Journal

Georgios Grammatikos, Nerea Ferreiros, Oliver Waidmann, Dimitra Bon, Sirkka Schroeter, Alexander Koch, Eva Hermann, Stefan Zeuzem, Bernd Kronenberger, Josef Pfeilschifter

Serum Sphingolipid Variations Associate with Hepatic Decompensation and Survival in Patients with Cirrhosis

2015, PloS one

Katja Schmitz, Nicole Mangels, Annett Haussler, Nerea Ferreiros, Ingrid Fleming, Irmgard Tegeder

Pro-inflammatory obesity in aged cannabinoid-2 receptor-deficient mice

2015, International Journal of Obesity

Katharina Syhr, Meike Boosen, Stephan Hohmann, Sebastian Longen, Yvette Kohler, Josef Pfeilschifter, Karl-Friedrich Beck, Gerd Geisslinger, Achim Schmidtko, Wiebke Kallenborn-Gerhardt

The H2S-producing enzyme CSE is dispensable for the processing of inflammatory and neuropathic pain

2015, Brain research

Alexandre Lacroix, Xavier Toussay Toussay, Eitan Anenberg, Clotilde Lecrux, Nerea Ferreiros, Anastassios Karagiannis, Fabrice Plaisier, Patrick Chausson, Frédéric Jarlier, Sean A Burgess, Elizabeth M. Hillman, Irmgard Tegeder, Timothy. H. Murphy, Edith Hamel, Bruno Cauli

COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex

2015, The Journal of neuroscience

Michael Isaac Meesters, Alexander Koch, Gerard Kuiper, Kai Zacharowski, Christa Boer

Instability of the non-activated rotational thromboelastometry assay (NATEM) in citrate stored blood

2015, Thrombosis research

Maria-Christina Scherzberg, Andreas Kiehl, Aleksandra Zivkovic, Holger Stark, Robert Fürst, Dieter Steinhilber, Sandra Ulrich-Rückert

Structural modification of resveratrol leads to increased anti-tumor activity, but causes profound changes in the mode of action

2015, Toxicology and applied pharmacology

Monica Villa Nova, Christine Janas, Mike Schmidt, Thomas Ulshöfer, Susanna Grafe, Susanne Schiffmann, Natasja de Bruin, Arno Wiehe, Volker Albrecht, Michael J. Parnham, Marcos Luciano Bruschi, Matthias G. Wacker

Nanocarriers for photodynamic therapy-rational formulation design and medium-scale manufacture

2015, International journal of pharmaceutics

Tobias M. Bingold, Rolf Lefering, Kai Zacharowski, Patrick Meybohm, Christian Waydhas, Peter Rosenberger, Bertram Scheller

Individual Organ Failure and Concomitant Risk of Mortality Differs According to the Type of Admission to ICU - A Retrospective Study of SOFA Score of 23,795 Patients

2015, PloS one

Bianca Gilbert, Khalil Ahmad, Jessica Roos, Christoph Lehmann, Tomohiro Chiba, Sandra Ulrich, Leonie Smeenk, Simon J. van Heeringen, Thorsten Maier, Bernd Groner, Dieter Steinhilber

5-Lipoxygenase is a direct p53 target gene in humans

2015, Biochimica et Biophysica Acta

Susanne Beyer, Aline Moosmann, Astrid Stefanie Kahnt, Thomas Ulshöfer, Michael J. Parnham, Nerea Ferreiros, Sylvia Wagner, Matthias G. Wacker

Drug Release and Targeting: the Versatility of Polymethacrylate Nanoparticles for Peroral Administration Revealed by Using an Optimized In Vitro-Toolbox

2015, Pharmaceutical research

Anika Berner, Malte Bachmann, Josef Pfeilschifter, Peter Kraiczy, Heiko Mühl

Interferon-alpha curbs production of interleukin-22 by human peripheral blood mononuclear cells exposed to live Borrelia burgdorferi

2015, Journal of cellular and molecular medicine

Jörn Lötsch, Violeta Dimova, Bruno Oertel

Reply to "Can topical capsaicin induce a neuropathic pain?

2015, Pain

Carmen Walter, Violeta Dimova, Julia Bu, Michael J. Parnham, Bruno Oertel, Jörn Lötsch

Inverted Perceptual Judgment of Nociceptive Stimuli at Threshold Level following Inconsistent Cues

2015, PLoS One

Katharina Syhr, Bruno Oertel, Gerd Geisslinger

Drug interactions in pain therapy

2015, Schmerz

Laura Sonnack, Sebastian Kampe, Elke Muth-Kohne, Lothar Erdinger, Nicole Henny, Henner Hollert, Christoph Schäfers, Martina Fenske

Effects of metal exposure on motor neuron development, neuromasts and the escape response of zebrafish embryos

2015, Neurotoxicology and teratology

John Bowes, Ashley Budu-Aggrey, Ulrike Hüffmeier, Steffen Uebe, Kathryn Audrey Steel, Harry Lidstone Hebert, Chris Wallace, Jonathon Massay, Ian N Bruce, James Bluett, Marie Feletar, Ann W. Morgan, Helena Marzo-Ortega, Gary Donohoe, Derek Morris, Philip S. Helliwell, Anthony W. Ryan, David Kane, Richard Warren, Eleanor Korendowych, Gerd-Marie Alenius, Emiliano Giardiana, Jon Packham, Ross McManus, Oliver Fitzgerald, Neil McHugh, Matthew A. Brown, Pauline Ho, Frank Behrens, Harald Burkhardt, André Reis, Anne Barton

Corrigendum: Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis

2015, Nature communications

Annika Wagner, Michaela Köhm, A. Nordin, E. Svenungsson, Josef Pfeilschifter, Heinfried H. Radeke

Increased Serum Levels of the IL-33 Neutralizing sST2 in Limited Cutaneous Systemic Sclerosis

2015, Scandinavian journal of immunology

Violeta Dimova, Bruno Oertel, Gulden Kabakci, Michael Zimmermann, Hanneke Hermens, Stefan Lautenbacher, Alfred Ultsch, Jörn Lötsch

A more pessimistic life orientation is associated with experimental inducibility of a neuropathy-like pain pattern in healthy individuals

2015, The journal of pain

Tanya S. King-Himmelreich, Otto Quintus Russe, Christine V. Möser, Nerea Ferreiros, Katharina Kynast, Claudia Knothe, Katrin Olbrich, Gerd Geisslinger

AMP-activated protein kinase is activated by non-steroidal anti-inflammatory drugs

2015, European journal of pharmacology

Alban Latremoliere, Alexandra Latini, Nick Andrews, Shane J. F. Cronin, Masahide Fujita, Katarzyna Gorska, Ruud Hovius, Carla Lt. Romero, Surawee Chuaipchichai, Michio W. Painter, Giulia Miracca, Olusegun Babajide Baniyi, Aline P. Remor, Kelly Duong, Priscilla Riva, Lee B. Barrett, Nerea Ferreiros, Alasdair Naylor, Josef M. Penninger, Irmgard Tegeder, Jian Zhong, Julian Blagg, Keith M. Channon, Kai Johnsson, Michael Costigan, Clifford J. Woolf

Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway

2015, Neuron

Carina Lindemann, Viola Marschall, Andreas Weigert, Thomas Klingebiel, Simone Fulda

Smac Mimetic-Induced Upregulation of CCL2/MCP-1 Triggers Migration and Invasion of Glioblastoma Cells and Influences the Tumor Microenvironment in a Paracrine Manner

2015, Neoplasia

Christina Dillmann, Javier Mora, Catherine Olesch, Bernhard Brüne, Andreas Weigert

S1PR4 is required for plasmacytoid dendritic cell differentiation

2015, Biological chemistry

Michaela Köhm, Frank Behrens

Pharmacotherapy of psoriatic arthritis. Treatment recommendations against the background of limited evidence

2015, Zeitschrift für Rheumatologie

Alfred Ultsch, Jörn Lötsch

Computed ABC Analysis for Rational Selection of Most Informative Variables in Multivariate Data

2015, PloS one

Dong Dong Zhang, Bona Linke, Jing Suo, Aleksandra Zivkovic, Yannick Schreiber, Nerea Ferreiros, Marina Henke, Gerd Geisslinger, Holger Stark, Klaus Scholich

Antinociceptive effects of FTY720 during trauma-induced neuropathic pain are mediated by spinal S1P receptors

2015, Biological chemistry

Frank Behrens, Paul P. Tak, Mikkel Ostergaard, Rumen Stoilov, Piotr Wiland, Thomas W. Huizinga, Vadym Y. Berenfus, Stoyanka Vladeva, Jürgen Rech, Andrea Rubbert-Roth, Marius Korkosz, Dmitriy Rekalov, Igor A. Zupanets, Bo Jannik Ejbjerg, Jens Geiseler, Julia Fresenius, Roman P Korolkiewicz, Arndt J. Schottelius, Harald Burkhardt

MOR103, a human monoclonal antibody to granulocyte-macrophage colony-stimulating factor, in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib/IIa randomised, double-blind, placebo-controlled, dose-escalation trial

2015, Annals of the rheumatic diseases

Tobias M. Bingold, Katharina Franck, Katharina Holzer, Kai Zacharowski, Wolf Bechstein, Heimo Wissing, Bertram Scheller

Intestinal Fatty Acid Binding Protein: A Sensitive Marker in Abdominal Surgery and Abdominal Infection

2015, Surgical infections

Albert Dahan, Jörn Lötsch

Morphine is not a prodrug.

2015, British Journal of Anaesthesia

Christine V. Möser, Heike Stephan, Katharina Altenrath, Katharina Kynast, Otto Quintus Russe, Katrin Olbrich, Gerd Geisslinger, Ellen Niederberger

TANK-binding kinase 1 (TBK1) modulates inflammatory hyperalgesia by regulating MAP kinases and NF-kappaB dependent genes

2015, Journal of neuroinflammation

Jörn Lötsch, Violeta Dimova, Isabel Lieb, Michael Zimmermann, Bruno Oertel, Alfred Ultsch

Multimodal distribution of human cold pain thresholds

2015, PLoS One

Andreas Lill, Carmen B. Rödl, Dieter Steinhilber, Holger Stark, Bettina Hofmann

Development and evaluation of ST-1829 based on 5-benzylidene-2-phenylthiazolones as promising agent for anti-leukotriene therapy

2015, European Journal of Medicinal Chemistry

Jingjing Xia, Jakub Michal Swiercz, Inmaculada Banon-Rodriguez, Ivana Matkovic, Giuseppina Federico, Tianliang Sun, Timo Franz, Cord H. Brakebusch, Atsushi Kumanogoh, Roland H. Friedel, Fernando Martin-Belmonte, Hermann-Josef Grone, Stefan Offermanns, Thomas Worzfeld

Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair

2015, Developmental Cell

Daniel Flesch, Matthias Gabler, Andreas Lill, Roberto Carrasco Gomez, Ramona Steri, Gisbert Schneider, Holger Stark, Manfred Schubert-Zsilavecz, Daniel Merk

Fragmentation of GW4064 led to a highly potent partial farnesoid X receptor agonist with improved drug-like properties

2015, Bioorganic & medicinal chemistry

Dario Kringel, Jörn Lötsch

Pain research funding by the European Union Seventh Framework Programme

2015, European journal of pain

Julia Barthelmes, Anika Männer de Bazo, Yael Pewzner-Jung, Katja Schmitz, Christoph Mayer, Christian Förch, Max Eberle, Nadja Tafferner, Nerea Ferreiros, Marina Henke, Gerd Geisslinger, Anthony Futerman, Sabine Grösch, Susanne Schiffmann

Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils

2015, Brain, behavior, and immunity

Dominique Thomas, Nikolas Herold, Oliver T. Keppler, Gerd Geisslinger, Nerea Ferreiros

Quantitation of endogenous nucleoside triphosphates and nucleosides in human cells by liquid chromatography tandem mass spectrometry

2015, Analytical and bioanalytical chemistry

Frank Behrens, Juan D. Canete, Ignazio Olivieri, Arno W. R. van Kuijk, Neil McHugh, Bernard Combe

Tumour necrosis factor inhibitor monotherapy vs combination with MTX in the treatment of PsA: a systematic review of the literature

2015, Rheumatology

Martin Feuchtenberger, Stefan Kleinert, Eva C Scharbatke, Holger Gnann, Frank Behrens, Bianca M. Wittig, Gerg Greger, Hans-Peter Tony

The impact of prior biologic therapy on adalimumab response in patients with rheumatoid arthritis

2015, Clinical and experimental rheumatology

Simone Fuchs, Loise Tzung-Harn Hsieh, Werner Saarberg, Clemens Erdelmeier, Thomas A. Wichelhaus, Liliana Schäfer, Egon Koch, Robert Fürst

Haemanthus coccineus extract and its main bioactive component narciclasine display profound anti-inflammatory activities in vitro and in vivo

2015, Journal of cellular and molecular medicine

Li Xie, Susanne Beyer, Vitali Vogel, Matthias G. Wacker, Werner Mantele

Assessing the drug release from nanoparticles: Overcoming the shortcomings of dialysis by using novel optical techniques and a mathematical model

2015, International journal of pharmaceutics

Max Eberle, Philipp Ebel, Christoph Mayer, Julia Barthelmes, Nadja Tafferner, Nerea Ferreiros, Thomas Ulshöfer, Marina Henke, Christian Förch, Anika Männer de Bazo, Sabine Grösch, Gerd Geisslinger, Klaus Willecke, Susanne Schiffmann

Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils

2015, Immunology and cell biology

Franca-Maria Klingler, Thomas A. Wichelhaus, Denia Frank, Jennifer Cuesta-Bernal, Jasmin El-Delik, Holger Florian Müller, Hanno Sjuts, Stephan Göttig, Arno Königs, Klaas M Pos, Denys Pogoryelov, Eugen Proschak

Approved Drugs Containing Thiols as Inhibitors of Metallo-beta-lactamases: Strategy To Combat Multidrug-Resistant Bacteria

2015, Journal of medicinal chemistry

Daniela Weth-Malsch, Camilla Bennetti, Caroline Rauch, Gerhard Gstraunthaler, Helmut Schmidt, Gerd Geisslinger, Roger Allen Sabbadini, Richard L. Proia, Michaela Kress

Activated platelets release sphingosine 1-phosphate and induce hypersensitivity to noxious heat stimuli in vivo

2015, Frontiers in neuroscience

Timo Wolf, Gerrit Kann, Stephan Becker, Christoph Stephan, Hans-Reinhard Brodt, Philipp de Leuw, Thomas Grünewald, Thomas Vogel, Volkhard Kempf, Oliver T. Keppler, Kai Zacharowski

Severe Ebola virus disease with vascular leakage and multiorgan failure: treatment of a patient in intensive care

2015, Lancet

Jörn Lötsch, Helena Daiker, Antje Hahner, Alfred Ultsch, Thomas Hummel

Drug-target based cross-sectional analysis of olfactory drug effects

2015, European journal of clinical pharmacology

Carmen Walter, Bruno Oertel, Jörn Lötsch

THC may reproducibly induce electrical hyperalgesia in healthy volunteers

2015, European journal of pain

Catherine Olesch, Weixiao Sha, Carlo Angioni, Lisa Sha, Elias Acaf, Paola Patrignani, Per-Johan Jakobsson, Heinfried H. Radeke, Sabine Grösch, Gerd Geisslinger, Andreas von Knethen, Andreas Weigert, Bernhard Brüne

MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer

2015, Oncotarget

Tilo Knape, Daniel Flesch, Laura Kuchler, Lisa Sha, Annika K Giegerich, Sandra Labocha, Mario Wurglics, Manfred Schubert-Zsilavecz, Eugen Proschak, Bernhard Brüne, Michael J. Parnham, Andreas von Knethen

Identification and characterisation of a prototype for a new class of competitive PPARgamma antagonists

2015, European journal of pharmacology

Thomas Vogel, Claudia Frellesen, Ralf W. Bauer, Matthias Kerl, Kai Zacharowski, Ingo Marzi, Thomas Hellwig, Renate Hammerstingl, Thomas Lehnert, Katrin Eichler

Multidisciplinary sliding-gantry CT: from concept to reality

2015, Journal of computer assisted tomography

Georgios Grammatikos, Nerea Ferreiros, Dimitra Bon, Stephanie Schwalm, Julia Dietz, Caterina Berkowski, Daniel Fitting, Eva Hermann, Stefan Zeuzem, Christoph Sarrazin, Josef Pfeilschifter

Variations in serum sphingolipid levels associate with liver fibrosis progression and poor treatment outcome in hepatitis C virus but not hepatitis B virus infection

2015, Hepatology

Jörn Lötsch, Violeta Dimova, Hanneke Hermens, Michael Zimmermann, Gerd Geisslinger, Bruno Oertel, Alfred Ultsch

Pattern of neuropathic pain induced by topical capsaicin application in healthy subjects

2015, Pain

Lisa Sha, Weixiao Sha, Laura Kuchler, Andreas Daiber, Annika K Giegerich, Andreas Weigert, Tilo Knape, Ryan Snodgrass, Katrin Schröder, Ralf Brandes, Bernhard Brüne, Andreas von Knethen

Loss of Nrf2 in bone marrow-derived macrophages impairs antigen-driven CD8(+) T cell function by limiting GSH and Cys availability

2015, Free radical biology & medicine

Anja Schmall, Hamza Al-Tamari, Susanne Herold, Marian Kampschulte, Andreas Weigert, Astrid Wietelmann, Natasha Vipotnik, Friedrich Grimminger, Werner Seeger, Soni S. Pullamsetti, Rajkumar Savai

Macrophage and cancer cell cross-talk via CCR2 and CX3CR1 is a fundamental mechanism driving lung cancer

2015, American journal of respiratory and critical care medicine

Julia Weber, Janosch Achenbach, Daniel Moser, Eugen Proschak

VAMMPIRE-LORD: a web server for straightforward lead optimization using matched molecular pairs

2015, Journal of chemical information and modeling

Kai Zacharowski, Hans-Reinhard Brodt, Timo Wolf

Medical treatment of an Ebola-infected doctor--ethics over costs?

2015, Lancet

Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis

2015, Nature communications

Daniel Moser, Sandra K. Wittmann, Jan Krämer, Janosch Achenbach, Denys Pogoryelov, Eugen Proschak

PENG: a neural gas-based approach for pharmacophore elucidation. method design, validation, and virtual screening for novel ligands of LTA4H

2015, Journal of chemical information and modeling

Daniel Flesch, Julia Ness, Christina Lamers, Friederike Dehm, Sven Popella, Isabella Ogorek, Martina Hieke, Gerd Dannhardt, Oliver Werz, Sascha Weggen, Manfred Schubert-Zsilavecz

SAR-studies of gamma-secretase modulators with PPARgamma-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease

2015, Bioorganic & medicinal chemistry letters

Yasmin Moran-Auth, Marissa Penna-Martinez, Klaus Badenhoop

VDR FokI polymorphism is associated with a reduced T-helper cell population under vitamin D stimulation in type 1 diabetes patients

2015, The Journal of steroid biochemistry and molecular biology

Andreas von Knethen, Lisa Sha, Tilo Knape, Laura Kuchler, Annika K Giegerich, Martin Schulz, Ingeborg Hauser, Bernhard Brüne

Activation of the peroxisome proliferator-activated receptor gamma counteracts sepsis-induced T cell cytotoxicity toward alloantigenic target cells

2015, Journal of Molecular Medicine

Ruirui Lu, Anne E. Bausch, Wiebke Kallenborn-Gerhardt, Carsten Stoetzer, Natasja de Bruin, Peter Ruth, Gerd Geisslinger, Andreas Leffler, Robert Lukowski, Achim Schmidtko

Slack channels expressed in sensory neurons control neuropathic pain in mice

2015, The Journal of neuroscience

Bettina Sehnert, Harald Burkhardt, Stefan Dübel, Reinhard E. Voll

The "sneaking-ligand" approach: cell-type specific inhibition of the classical NF-kappaB pathway

2015, Methods in molecular biology

Bettina Sehnert, Harald Burkhardt, Michael J. May, Jochen Zwerina, Reinhard E. Voll

Sneaking-ligand fusion proteins attenuate serum transfer arthritis by endothelium-targeted NF-kappaB inhibition

2015, Methods in molecular biology

Diamant Thaci, Frank Behrens, Gerg Greger, Harald Burkhardt, Holger Gnann, R. Schopf

Association between skin and joint involvement in patients with psoriatic arthritis treated with adalimumab: analysis of data from a German non-interventional study

2015, Dermatology

Marco Koch, Nerea Ferreiros, Gerd Geisslinger, Faramarz Dehghani, Horst-Werner Korf

Rhythmic control of endocannabinoids in the rat pineal gland

2015, Chronobiology international

Jörn Lötsch, Thomas Hummel

2015, Chemical senses

Bruno Oertel, Tao T. Huynh, Thomas Hummel, Jörn Lötsch

Lack of fluconazole effects on human chemosensation

2015, International journal of clinical pharmacology and therapeutics

Natasja de Bruin, C. G. Kruse

5-HT6 Receptor Antagonists: Potential Efficacy for the Treatment of Cognitive Impairment in Schizophrenia

2015, Current pharmaceutical design

Daniel Merk, Christina Lamers, Julia Weber, Daniel Flesch, Matthias Gabler, Eugen Proschak, Manfred Schubert-Zsilavecz

Anthranilic acid derivatives as nuclear receptor modulators--development of novel PPAR selective and dual PPAR/FXR ligands

2014, Bioorganic & Medicinal Chemistry

Karl-Friedrich Beck, Johannes Euler, Florian Eisel, Martina Beck, Yvette Kohler, Lisa Sha, Andreas von Knethen, Sebastian Longen, Josef Pfeilschifter

Cytokines induce protein kinase A-mediated signalling by a redox-dependent mechanism in rat renal mesangial cells

2014, Biochemical pharmacology

Katja Schmitz, Julia Barthelmes, Leonie Stolz, Susanne Beyer, Olaf Diehl, Irmgard Tegeder

"Disease modifying nutricals" for multiple sclerosis

2014, Pharmacology & therapeutics

Laura Kuchler, Annika K Giegerich, Lisa Sha, Tilo Knape, Michael Wong, Katrin Schröder, Ralf Brandes, Heinrich Heide, Ilka Wittig, Bernhard Brüne, Andreas von Knethen

SYNCRIP-Dependent Nox2 mRNA Destabilization Impairs ROS Formation in M2-Polarized Macrophages

2014, Antioxidants & redox signaling

Harald Farnik, Nerea Ferreiros, Sandra Labocha, Gerd Geisslinger, Stefan Zeuzem, Christoph Sarrazin, Johannes Vermehren

Role of telaprevir plasma levels for predicting response to antiviral therapy in patients with hepatitis C virus genotype 1 infection

2014, Scandinavian journal of gastroenterology

Bruno Oertel, Johannes Vermehren, Tao T. Huynh, Alexandra Doehring, Nerea Ferreiros, Michael Zimmermann, Gerd Geisslinger, Jörn Lötsch

Cytochrome P450 epoxygenase dependence of opioid analgesia: fluconazole does not interfere with remifentanil-mediated analgesia in human subjects

2014, Clinical pharmacology and therapeutics

Marco Sisignano, Ralf Baron, Klaus Scholich, Gerd Geisslinger

Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain

2014, Nature reviews. Neurology

Klaus Badenhoop

Genetics: Vitamin D and type 2 diabetes mellitus - hype or hope?

2014, Nature reviews - Endocrinology

Susanne Beyer, Li Xie, Susanna Grafe, Kerstin Dietrich, Arno Wiehe, Volker Albrecht, Werner Mantele, Matthias G. Wacker

Bridging laboratory and large scale production: preparation and in vitro-evaluation of photosensitizer-loaded nanocarrier devices for targeted drug delivery

2014, Pharmaceutical research

Max Eberle, Philipp Ebel, Marthe-Susanna Wegner, Julia Barthelmes, Nadja Tafferner, Nerea Ferreiros, Kerstin Birod, Yannick Schreiber, Gurumoorthy Krishnamoorthy, Klaus Willecke, Gerd Geisslinger, Sabine Grösch, Susanne Schiffmann

Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent

2014, Biochemical pharmacology

Lisa Baumann, Susanne Knörr, Susanne Keiter, Tina Nagel, Kristina Rehberger, Sina Volz, Sophia Oberrauch, Viktoria Schiller, Martina Fenske, Henrik Holbech, Helmut Segner, Thomas Braunbeck

Persistence of endocrine disruption in zebrafish (Danio rerio) after discontinued exposure to the androgen 17beta-trenbolone

2014, Environmental Toxicology and Chemistry

Jan Christoph Guder, Markus Buchhaupt, Ina Huth, Achim Hannappel, Nerea Ferreiros, Gerd Geisslinger, Jens Schrader

Biotechnological approach towards a highly efficient production of natural prostaglandins

2014, Biotechnology letters

Dominique Thomas, Jing Suo, Thomas Ulshöfer, Holger Jordan, Natasja de Bruin, Klaus Scholich, Gerd Geisslinger, Nerea Ferreiros

Nano-LC-MS/MS for the quantitation of prostanoids in immune cells

2014, Analytical and bioanalytical chemistry

Alfred Ultsch, Jörn Lötsch

What do all the (human) micro-RNAs do?

2014, BMC Genomics

Carmen Walter, Bruno Oertel, Dagmar Ludyga, Alfred Ultsch, Thomas Hummel, Jörn Lötsch

Effects of 20 mg oral Delta(9) -tetrahydrocannabinol on the olfactory function of healthy volunteers

2014, British journal of clinical pharmacology

Katharina Syhr, Gerd Geisslinger, Bruno Oertel

Arzneimittelinteraktionen in der Schmerztherapie

2014, CME-Artikel, Pfizer Pharma GmbH

Jana Lorenz, Wiebke Kallenborn-Gerhardt, Ruirui Lu, Katharina Syhr, Philip Eaton, Gerd Geisslinger, Achim Schmidtko

Oxidant-induced activation of cGMP-dependent protein kinase Iα mediates neuropathic pain after peripheral nerve injury

2014, Antioxid Redox Signal

Wiebke Kallenborn-Gerhardt, Stephan Hohmann, Katharina Syhr, Katrin Schröder, Marco Sisignano, Andreas Weigert, Jana Lorenz, Ruirui Lu, Bernhard Brüne, Ralf Brandes, Gerd Geisslinger, Achim Schmidtko

Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity

2014, Pain

Jörn Lötsch, Bruno Oertel, Alfred Ultsch

Human models of pain for the prediction of clinical analgesia

2014, Pain

Jennifer Scheel, Andreas Parthum, Violeta Dimova, Claudia Horn-Hoffmann, Florian Meinfelder, Roman Carbon, Norbert Griessinger, Reinhard Sittl, Stefan Lautenbacher

Psychologisches Prophylaxetraining zur Bewältigung postoperativer Schmerzen

2014, Der Schmerz

Viktoria Schiller, Xiaowei Zhang, Markus Hecker, Christoph Schäfers, Rainer Fischer, Martina Fenske

Species-specific considerations in using the fish embryo test as an alternative to identify endocrine disruption

2014, Aquatic toxicology

Jessica Roos, Claudia Oancea, Maria Heinssmann, Dilawar Khan, Hannelore Held, Astrid Stefanie Kahnt, Ricardo Capelo, Estel la Buscato, Eugen Proschak, Elena Puccetti, Dieter Steinhilber, Ingrid Fleming, Thorsten Maier, Martin Ruthard

5-Lipoxygenase is a candidate target for therapeutic management of stem cell-like cells in acute myeloid leukemia

2014, Cancer research

Katja Schmitz, Natasja de Bruin, Philipp Bishay, Julia Barthelmes, Annett Haussler, Christine Altmann, Nerea Ferreiros, Jörn Lötsch, Alfred Ultsch, Michael J. Parnham, Gerd Geisslinger, Irmgard Tegeder

R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice

2014, EMBO molecular medicine

Katharina Syhr, Wiebke Kallenborn-Gerhardt, Ruirui Lu, Katrin Olbrich, Katja Schmitz, Julia Barthelmes, Nerea Ferreiros, Gerd Geisslinger, Ellen Niederberger, Achim Schmidtko

Lack of effect of a P2Y6 receptor antagonist on neuropathic pain behavior in mice

2014, harmacology, biochemistry, and behavior

Nerea Ferreiros, Julia Homann, Sandra Labocha, Nina Grossmann, Julia S. Hahn, Bernhard Brüne, Gerd Geisslinger

Lipoxin A(4): problems with its determination using reversed phase chromatography-tandem mass spectrometry and confirmation with chiral chromatography

2014, Talanta

Julia Homann, Christoph Lehmann, Astrid Stefanie Kahnt, Dieter Steinhilber, Michael J. Parnham, Gerd Geisslinger, Nerea Ferreiros

Chiral chromatography-tandem mass spectrometry applied to the determination of pro-resolving lipid mediators

2014, Journal of chromatography

Bassem Sadek, Annemarie Schreeb, Johannes Stephan Schwed, Lilia Weizel, Holger Stark

Drug-likeness approach of 2-aminopyrimidines as histamine H3 receptor ligands

2014, Drug design, development and therapy

Michael Wong, Matthias S. Leisegang, C. G. Kruse, Juri Vogel, Christoph Schurmann, Nathalie Dehne, Andreas Weigert, Eva Hermann, Bernhard Brüne, Ajay M. Shah, Dieter Steinhilber, Stefan Offermanns, Geert Carmeliet, Klaus Badenhoop, Katrin Schröder, Ralf Brandes

Vitamin D promotes vascular regeneration

2014, Circulation

Lisa Baumann, Susanne Knörr, Susanne Keiter, Kristina Rehberger, Sina Volz, Viktoria Schiller, Martina Fenske, Henrik Holbech, Helmut Segner, Thomas Braunbeck

Reversibility of endocrine disruption in zebrafish (Danio rerio) after discontinued exposure to the estrogen 17alpha-ethinylestradiol

2014, Toxicology and Applied Pharmacology

Wiebke Kallenborn-Gerhardt, Ruirui Lu, Aaron Bothe, Dominique Thomas, Jessica Schlaudraff, Jana Lorenz, Nancy Lippold, Catherine I. Real, Nerea Ferreiros, Gerd Geisslinger, Domenico Del Turco, Achim Schmidtko

Phosphodiesterase 2A localized in the spinal cord contributes to inflammatory pain processin

2014, Anesthesiology

Michael J. Parnham, Vesna Erakovic Haber, Evangelos J. Giamarellos-Bourboulis, Gianpaolo Perletti, Geert M Verleden, Robin Vos

Azithromycin: mechanisms of action and their relevance for clinical applications

2014, Pharmacology & therapeutics

Khader Awwad, Svenja Steinbrink, Timo Frömel, Nicole Mangels, Johann Isaak, Ann-Kathrin Häfner, Jessica Roos, Bettina Hofmann, Heinrich Heide, Gerd Geisslinger, Dieter Steinhilber, Bruce Freeman, Thorsten Maier, Ingrid Fleming

Electrophilic Fatty Acid Species Inhibit 5-Lipoxygenase and Attenuate Sepsis-Induced Pulmonary Inflammation

2014, Antioxidants & redox signaling

Lisa Felden, Carmen Walter, Carlo Angioni, Yannick Schreiber, Nils von Hentig, Nerea Ferreiros, Gerd Geisslinger, Jörn Lötsch

2014, Pharmaceutical Research

Jing Suo, Bona Linke, Sascha Meyer Dos Santos, Sandra Pierre, David Stegner, Dong Dong Zhang, Cecile V Denis, Gerd Geisslinger, Bernhard Nieswandt, Klaus Scholich

Neutrophils mediate edema formation but not mechanical allodynia during zymosan-induced inflammation

2014, Journal of leukocyte biology

Sabrina Haag, Nadine Schneider, Daniel E. Mason, Jonatan Tuncel, Ida E. Andersson, Eric Peters, Harald Burkhardt, Rikard Holmdahl

Identification of new citrulline-specific autoantibodies, which bind to human arthritic cartilage, by mass spectrometric analysis of citrullinated type II collagen

2014, Arthritis & Rheumatology

Rikard Holmdahl, Vivianne Malmström, Harald Burkhardt

Autoimmune priming, tissue attack and chronic inflammation - the three stages of rheumatoid arthritis

2014, European journal of immunology

Michael Schütz, Bruno Oertel, Dirk Heimann, Alexandra Doehring, Carmen Walter, Violeta Dimova, Gerd Geisslinger, Jörn Lötsch

Consequences of a human TRPA1 genetic variant on the perception of nociceptive and olfactory stimuli

2014, PLoS One

Otto Quintus Russe, Christine V. Möser, Katharina Kynast, Tanya S. King-Himmelreich, Katrin Olbrich, Sabine Grösch, Gerd Geisslinger, Ellen Niederberger

LPS inhibits caspase 3-dependent apoptosis in RAW264.7 macrophages induced by the AMPK activator AICAR

2014, Biochemical and biophysical research communications

Vera Delov, Elke Muth-Kohne, Christoph Schäfers, Martina Fenske

Transgenic fluorescent zebrafish Tg(fli1:EGFP)y(1) for the identification of vasotoxicity within the zFET

2014, Aquatic Toxicology

Dmitry Namgaladze, Sebastian Lips, Thomas J Leiker, Robert C Murphy, Kim Ekroos, Nerea Ferreiros, Gerd Geisslinger, Bernhard Brüne

Inhibition of macrophage fatty acid beta-oxidation exacerbates palmitate-induced inflammatory and endoplasmic reticulum stress responses

2014, Diabetologia

Sebastian Sailler, Katja Schmitz, Elke Jäger, Nerea Ferreiros, Sabine Wicker, Katja Zschiebsch, Geethanjali Pickert, Gerd Geisslinger, Carmen Walter, Irmgard Tegeder, Jörn Lötsch

Regulation of circulating endocannabinoids associated with cancer and metastasis in mice and humans

2014, Oncoscience

Daniel Merk, Matthias Gabler, Roberto Carrasco Gomez, Daniel Flesch, Thomas Hanke, Astrid Kaiser, Christina Lamers, Oliver Werz, Gisbert Schneider, Manfred Schubert-Zsilavecz

Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR)

2014, Bioorganic & medicinal chemistry

John M. Dawes, Ana Antunes-Martins, James R. Perkins, Kathryn J. Paterson, Marco Sisignano, Ramona Schmid, Werner Rust, Tobias Hildebrandt, Gerd Geisslinger, Christine Orengo, David L. H. Bennett, Stephen B. McMahon

Genome-wide transcriptional profiling of skin and dorsal root ganglia after ultraviolet-B-induced inflammation

2014, PLoS One

Nerea Ferreiros, Sandra Labocha, Juliane El-Duweik, Christina Schlecker, Jörn Lötsch, Gerd Geisslinger

Quantitation of ribavirin in human plasma and red blood cells using LC-MS/MS

2014, Journal of separation science

Ruirui Lu, Robert Lukowski, Matthias Sausbier, Dong Dong Zhang, Marco Sisignano, Claus-Dieter Schuh, Rohini Kuner, Peter Ruth, Gerd Geisslinger, Achim Schmidtko

BKCa channels expressed in sensory neurons modulate inflammatory pain in mice

2014, Pain

Claus-Dieter Schuh, Sandra Pierre, Andreas Weigert, Benjamin Weichand, Kai Altenrath, Yannick Schreiber, Nerea Ferreiros, Dong Dong Zhang, Jing Suo, Elsa-Marie Treutlein, Marina Henke, Hana Kungel, Manuel Grez, Rolf Nüsing, Bernhard Brüne, Gerd Geisslinger, Klaus Scholich

Prostacyclin mediates neuropathic pain through interleukin 1beta-expressing resident macrophages

2014, Pain

Matthias G. Wacker

Nanotherapeutics--product development along the "nanomaterial" discussion

2014, Journal of pharmaceutical sciences

Susanne Schiffmann, Andreas Weigert, Julia Barthelmes, Max Eberle, Kerstin Birod, Annett Haussler, Nerea Ferreiros, Yannick Schreiber, Manuel Grez, Benjamin Weichand, Bernhard Brüne, Waltraud Pfeilschifter, Rolf Nüsing, Ellen Niederberger, Sabine Grösch, Klaus Scholich, Gerd Geisslinger

PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis

2014, Biochemical pharmacology

Jörn Lötsch, Thomas Hummel, Ulrich Warskulat, Ovidiu Coste, Dieter Haussinger, Gerd Geisslinger, Irmgard Tegeder

Congenital taurine deficiency in mice is associated with reduced sensitivity to nociceptive chemical stimulation

2014, Neuroscience

Claus-Dieter Schuh, Christian Brenneis, Dong Dong Zhang, Carlo Angioni, Yannick Schreiber, Nerea Ferreiros, Sandra Pierre, Marina Henke, Bona Linke, Rolf Nüsing, Klaus Scholich, Gerd Geisslinger

Prostacyclin regulates spinal nociceptive processing through cyclic adenosine monophosphate-induced translocation of glutamate receptors

2014, Anesthesiology

Alfred Ultsch, Jörn Lötsch

Functional abstraction as a method to discover knowledge in gene ontologies

2014, PloS one

Christian Brenneis, Katrin Kistner, Michelino Puopolo, Sooyeon Jo, D.P. Roberson, Marco Sisignano, David Segal, Enrique José Cobos, Brian J. Wainger, Sandra Labocha, Nerea Ferreiros, Christian A. von Hehn, Johnathan Tran, Gerd Geisslinger, Peter W. Reeh, Bruce P. Bean, Clifford J. Woolf

Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block

2014, British Journal of Pharmacology

Manfred Schubert-Zsilavecz, Daniel Flesch

Phosphodiesterasen - Attraktive Ziele für Arzneistoffe

2014, Pharmazeutische Zeitung

Annika K Giegerich, Laura Kuchler, Lisa K. Sha, Tilo Knape, Heinrich Heide, Ilka Wittig, Christian Behrends, Bernhard Brüne, Andreas von Knethen

Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression

2014, Autophagy

Marco Sisignano, David L. H. Bennett, Gerd Geisslinger, Klaus Scholich

TRP-channels as key integrators of lipid pathways in nociceptive neurons

2014, Progress in lipid research

Matthias G. Wacker

Quo vadis Nano? / Nanomaterialien in der pharmazeutischen Produktentwicklung

2014, Die Pharmazeutische Industrie

Thomas Hanke, Florian Rörsch, Theresa M. Thieme, Nerea Ferreiros, Gisbert Schneider, Gerd Geisslinger, Eugen Proschak, Sabine Grösch, Manfred Schubert-Zsilavecz

Synthesis and pharmacological characterization of benzenesulfonamides as dual species inhibitors of human and murine mPGES-1

2013, Bioorganic & Medicinal Chemistry

Jörn Lötsch, Gisbert Schneider, Daniel Reker, Michael J. Parnham, Petra Schneider, Gerd Geisslinger, Alexandra Doehring

Common non-epigenetic drugs as epigenetic modulators

2013, Trends in Molecular Medicine

Marco Sisignano, Carlo Angioni, Nerea Ferreiros, Claus-Dieter Schuh, Jing Suo, Yannick Schreiber, John M. Dawes, Ana Antunes-Martins, David L. H. Bennett, Stephen B. McMahon, Gerd Geisslinger, Klaus Scholich

Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice

2013, PLoS One

Miriam Tomasch, Johannes Stephan Schwed, Alexander Paulke, Holger Stark

Bodilisant-a novel fluorescent, highly affine histamine h3 receptor ligand

2013, ACS Medicinal Chemistry Letters

Andreas von Knethen, Lisa K. Sha, Laura Kuchler, Annika K. Heeg, Dominik Fuhrmann, Heinrich Heide, Ilka Wittig, Thorsten Maier, Dieter Steinhilber, Bernhard Brüne

5-Lipoxygenase contributes to PPARgamma activation in macrophages in response to apoptotic cells

2013, Cellular Signalling

Kerstin Wingen, Holger Stark

Scaffold variations in amine warhead of histamine H(3) receptor antagonists

2013, Drug Discovery Today: Technologies

Claudia Goettsch, Andrea Babelova, Olivia Trummer, Reinhold Erben, Martina Rauner, Norbert Weissmann, Valeska Helfinger, Sebastian Benkhoff, Marian Kampschulte, Barbara Obermayer-Pietsch, Lorenz Hofbauer, Ralf Brandes, Katrin Schröder

NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis

2013, The Journal of clinical investigation

Philip J. Mease, Dafna D. Gladman, Kim A. Papp, Majed M. Khraishi, Diamant Thaci, Frank Behrens, Robert Northington, Joanne Fuiman, Eustratios Bananis, Robert Boggs, Daniel Alvarez

Prevalence of rheumatologist-diagnosed psoriatic arthritis in patients with psoriasis in European/North American dermatology clinics

2013, Journal of the American Academy of Dermatology

Michael J. Parnham, Helmut Sies

The early research and development of ebselen

2013, Biochemical Pharmacology

Otto Quintus Russe, Christine V. Möser, Katharina Kynast, Tanya S. King-Himmelreich, Heike Stephan, Gerd Geisslinger, Ellen Niederberger

Activation of the AMP-activated protein kinase reduces inflammatory nociception

2013, Journal of Pain

Dominique Thomas, Max Eberle, Susanne Schiffmann, Dong Dong Zhang, Gerd Geisslinger, Nerea Ferreiros

Nano-LC-MS/MS for the quantitation of ceramides in mice cerebrospinal fluid using minimal sample volume

2013, Talanta

Carmen Walter, Alexandra Doehring, Bruno Oertel, Jörn Lötsch

micro-opioid receptor gene variant OPRM1 118 A>G: a summary of its molecular and clinical consequences for pain

2013, Pharmacogenomics

Janosch Achenbach, Franca-Maria Klingler, Rene Blöcher, Daniel Moser, Ann-Kathrin Häfner, Carmen B. Rödl, Simon Kretschmer, Bjorn Kruger, Dr. Frank Lohr, Holger Stark, Bettina Hofmann, Dieter Steinhilber, Eugen Proschak

Exploring the chemical space of multitarget ligands using aligned self-organizing maps

2013

Frank Behrens, Hans-Peter Tony, Rieke Alten, Stefan Kleinert, Eva C Scharbatke, Michaela Köhm, Holger Gnann, Johanna Tams, Gerg Greger, Harald Burkhardt

Development and validation of a new disease activity score in 28 joints-based treatment response criterion for rheumatoid arthritis

2013, Arthritis Care & Research

Jörn Lötsch, Carsten Skarke, Jutta Darimont, Michael Zimmermann, Lutz Bräutigam, Gerd Geisslinger, Alfred Ultsch, Bruno Oertel

Non-invasive combined surrogates of remifentanil blood concentrations with relevance to analgesia

2013, Naunyn-Schmiedeberg's Archives of Pharmacology

Jörn Lötsch, Alfred Ultsch

A machine-learned knowledge discovery method for associating complex phenotypes with complex genotypes. Application to pain

2013, Journal of Biomedical Informatics

Sascha Meyer Dos Santos, Anita Zorn, Zeno Guttenberg, Bettina Picard-Willems, Christina Kläffling, Karen Nelson, Ute Klinkhardt, Sebastian Harder

A novel mu-fluidic whole blood coagulation assay based on Rayleigh surface-acoustic waves as a point-of-care method to detect anticoagulants

2013, Biomicrofluidics

Stephany Micallef, Holger Stark, Astrid Sasse

Polymorphisms and genetic linkage of histamine receptors

2013, Life Sciences

Nathalie Dehne, Silke Essler, Theresa Geis, Tobias Schmid, Bernhard Brüne

IL-4 reduces the proangiogenic capacity of macrophages by down-regulating HIF-1alpha translation

2013, Journal of leukocyte biology

Stefanie Grunwald, Julia Stellzig, Iris V. Adam, Kristine Weber, Sarai Binger, Michael Boll, Eileen Knorr, Richard M. Twyman, Andreas Vilcinskas, Uwe Wenzel

Longevity in the red flour beetle Tribolium castaneum is enhanced by broccoli and depends on nrf-2, jnk-1 and foxo-1 homologous genes

2013, Genes & Nutrition

Susanne Schiffmann, Kerstin Birod, Julia Barthelmes, Max Eberle, Marthe-Susanna Wegner, Ruth Wanger, Daniela Hartmann, Nerea Ferreiros, Gerd Geisslinger, Sabine Grösch

Ceramide metabolism in mouse tissue

2013, The international journal of biochemistry & cell biology

Philipp Bishay, Annett Haussler, Hee-Young Lim, Bruno Oertel, Ismael Galve-Roperh, Nerea Ferreiros, Irmgard Tegeder

Anandamide deficiency and heightened neuropathic pain in aged mice

2013, Neuropharmacology

Ellen Niederberger, Christine V. Möser, Katharina Kynast, Gerd Geisslinger

The non-canonical IkappaB kinases IKKepsilon and TBK1 as potential targets for the development of novel therapeutic drugs

2013, Current Molecular Medicine

Amine Bahi, Bassem Sadek, Johannes Stephan Schwed, Carmen Walter, Holger Stark

Influence of the novel histamine H(3) receptor antagonist ST1283 on voluntary alcohol consumption and ethanol-induced place preference in mice

2013, Psychopharmacology

Robert Brunkhorst, Nathalie Kanaan, Alexander Koch, Nerea Ferreiros, Ana Mirceska, Pia Zeiner, Michel Mittelbronn, Amin Derouiche, Christian Förch, Josef Pfeilschifter, Waltraud Pfeilschifter

FTY720 treatment in the convalescence period improves functional recovery and reduces reactive astrogliosis in photothrombotic stroke

2013, PLOS ONE

Dirk Heimann, Jörn Lötsch, Thomas Hummel, Alexandra Doehring, Bruno Oertel

Linkage between increased nociception and olfaction via a SCN9A haplotype

2013, PLoS One

Jörn Lötsch, Alexandra Doehring, Jeffrey S. Mogil, Torsten Arndt, Gerd Geisslinger, Alfred Ultsch

Functional genomics of pain in analgesic drug development and therapy

2013, Pharmacology & Therapeutics

Annemarie Schreeb, Michael Walter, Dalibor Odadzic, Johannes Stephan Schwed, Lilia Weizel, Holger Stark

Piperazine modification in 2,4,6-triaminopyrimidine derivatives as histamine H4 receptor ligands

2013, Die Pharmazie

Dominik Bergis, Valentin Kassis, Annika Wagner, Verena Koeberle, Albrecht Piiper, Bernd Kronenberger, Stefan Zeuzem, Oliver Waidmann, Heinfried H. Radeke

High Serum Levels of the Interleukin-33 Receptor Soluble ST2 as a Negative Prognostic Factor in Hepatocellular Carcinoma

2013, Translational oncology

Julien Hanson, Nerea Ferreiros, Bernard Pirotte, Gerd Geisslinger, Stefan Offermanns

Heterologously expressed formyl peptide receptor 2 (FPR2/ALX) does not respond to lipoxin A(4)

2013, Biochemical Pharmacology

Astrid Stefanie Kahnt, Florian Rörsch, Olaf Diehl, Bettina Hofmann, Christoph Lehmann, Svenja Steinbrink, Carlo Angioni, Gerd Geisslinger, Sabine Grösch, Thorsten Maier

Cysteinyl leukotriene-receptor-1 antagonists interfere with PGE synthesis by inhibiting mPGES-1 activity

2013, Biochemical pharmacology

Daniela Hartmann, Marthe-Susanna Wegner, Nerea Ferreiros, Yannick Schreiber, Jessica Lucks, Susanne Schiffmann, Gerd Geisslinger, Sabine Grösch

The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS

2013, The International Journal of Biochemistry & Cell Biology

Tilo Wuensch, Stephan Schulz, Sina Ullrich, Nicole Mangels, Tamara Stelzl, Isabel Rubio-Aliaga, Mathias Chamaillard, Gunnar Loh, Dirk Haller, Hannelore Daniel

The peptide transporter PEPT1 is expressed in distal colon in rodents and humans and contributes to water absorption

2013, American journal of physiology. Gastrointestinal and liver physiology

Rudiger Popp, Katja Schmitz, Geethanjali Pickert, Nina Wijnvoord Wijnvoord, Annett Haussler, Irmgard Tegeder

Dichotomy of CCL21 and CXCR3 in nerve injury-evoked and autoimmunity-evoked hyperalgesia

2013, Brain, behavior, and immunity

Maria Apel, Steffen Uebe, John Bowes, Emiliano Giardiana, Eleanor Korendowych, Kristina Juneblad, Francesca Pasutto, Arif B Ekici, Ross McManus, Pauline Ho, Ian N Bruce, Anthony W. Ryan, Frank Behrens, Beate Bohm, Heiko Traupe, Jörg Lohmann, Christian Gieger, Heinz-Erich Wichmann, Leonid Padyukov, Oliver Fitzgerald, Gerd-Marie Alenius, Neil McHugh, Giuseppe Novelli, Harald Burkhardt, André Reis, Ulrike Hüffmeier

Variants in RUNX3 contribute to susceptibility to psoriatic arthritis, exhibiting further common ground with ankylosing spondylitis

2013, Arthritis & Rheumatology

Natasja de Bruin, Martin van Drimmelen, Marjolein Kops, J. van Elk, MM. Wetering, Isabel Schwienbacher

Effects of risperidone, clozapine and the 5-HT6 antagonist GSK-742457 on PCP-induced deficits in reversal learning in the two-lever operant task in male Sprague Dawley rats

2013, Behavioural Brain Research

Rainer Freynhagen, Gerd Geisslinger, Stephan A. Schug

Opioids for chronic non-cancer pain

2013, British Medical Journal

Katharina Kynast, Otto Quintus Russe, Gerd Geisslinger, Ellen Niederberger

Novel findings in pain processing pathways: implications for miRNAs as future therapeutic targets

2013, Expert Review of Neurotherapeutics

Heiko Mühl, Patrick Scheiermann, Malte Bachmann, Lorena Hardle, Anika Berner, Josef Pfeilschifter

IL-22 in tissue protective therapy

2013, British journal of pharmacology

Wiebke Kallenborn-Gerhardt, Ruirui Lu, Katharina Syhr, Juliana Heidler, Harald von Melchner, Gerd Geisslinger, Thorsten Bangsow, Achim Schmidtko

Antioxidant activity of Sestrin 2 controls neuropathic pain after peripheral nerve injury

2013, Antioxidants & redox signaling

Alexander Visekruna, Josephine Ritter, Tatjana Scholz, Lucia Campos, Anna Guralnik, Lucia Poncette, Hartmann Raifer, Stefanie Hagner, Holger Garn, Valerie Staudt, Tobias Bopp, Sebastian Reuter, Christian Taube, Karin Loser, Magdalena Huber

Tc9 cells, a new subset of CD8+ T cells, support Th2-mediated airway inflammation

2013, European journal of immunology

Frank Behrens, Christoph Finkenwirth, Karel Pavelka, Jirí Stolfa, Alenka Sipek-Dolnicar, Diamant Thaci, Harald Burkhardt

Leflunomide in psoriatic arthritis: results from a large European prospective observational study

2013, Arthritis Care & Research

Wiebke Kallenborn-Gerhardt, Katrin Schröder, Gerd Geisslinger, Achim Schmidtko

NOXious signaling in pain processing

2013, Pharmacology & Therapeutics

Katharina Kynast, Otto Quintus Russe, Christine V. Möser, Gerd Geisslinger, Ellen Niederberger

Modulation of central nervous system-specific microRNA-124a alters the inflammatory response in the formalin test in mice

2013, Pain

Ken T. Coppieters, Natalie Amirian, Philippe P. Pagni, Carmen Baca Pagni, Anna Wiberg, Stanley Lasch, Edith Hintermann, Urs Christen, Matthias G. von Herrath

Functional redundancy of CXCR3/CXCL10 signaling in the recruitment of diabetogenic CTL to pancreatic islets in a virally induced autoimmune diabetes model

2013, Diabetes

Yasmin Moran-Auth, Marissa Penna-Martinez, F. Shoghi, Elisabeth Ramos-Lopez, Klaus Badenhoop

Vitamin D status and gene transcription in immune cells

2013, The Journal of steroid biochemistry and molecular biology

Frank Behrens, Michaela Köhm

Personalized medicine in cytokine-targeted therapy

2013, Enthält auch Ergebnisse für Z Rheumatology. Nur nach Z Rheumatol. suchen Suchergebnisse Zeitschrift für Rheumatologie

Nerea Ferreiros, Sandra Labocha, Carmen Walter, Jörn Lötsch, Gerd Geisslinger

Simultaneous and sensitive LC-MS/MS determination of tetrahydrocannabinol and metabolites in human plasma

2013, Analytical and Bioanalytical Chemistry

Karin Meirer, Carmen B. Rödl, Joanna M. Wisniewska, Sven George, Ann-Kathrin Häfner, Estel la Buscato, Franca-Maria Klingler, Steffen Hahn, Dirk Berressem, Sandra K. Wittmann, Dieter Steinhilber, Bettina Hofmann, Eugen Proschak

Synthesis and structure-activity relationship studies of novel dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase

2013, Journal of Medicinal Chemistry

Bruno Oertel, Jörn Lötsch

Clinical pharmacology of analgesics assessed with human experimental pain models: bridging basic and clinical research

2013, British Journal of Pharmacology

Geethanjali Pickert, Hee-Young Lim, Andreas Weigert, Annett Haussler, Thekla Myrczek, Maximilian Waldner, Sandra Labocha, Nerea Ferreiros, Gerd Geisslinger, Jörn Lötsch, Christoph Becker, Bernhard Brüne, Irmgard Tegeder

Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages

2013, International Journal of Cancer

Daniel Flesch, Daniel Merk, Christina Lamers, Manfred Schubert-Zsilavecz

Novel prostaglandin receptor modulators--part II: EP receptor modulators; a patent review (2002 - 2012)

2013, Expert opinion on therapeutic patents

Daniel Flesch, Manfred Schubert-Zsilavecz

Orale Antidiabetika in der klinischen Entwicklung

2013, Pharmakon

Annely Brandt, Andreas Vilcinskas

The Fruit Fly Drosophila melanogaster as a Model for Aging Research

2013, Advances in Biochemical Engineering / Biotechnology

Natasja de Bruin, A. C. McCreary, Arnold van Loevezijn, T. J. de Vries, Jennifer Venhorst, Martin van Drimmelen, C. G. Kruse

A novel highly selective 5-HT6 receptor antagonist attenuates ethanol and nicotine seeking but does not affect inhibitory response control in Wistar rats

2013, Behavioural Brain Research

Alexandra Doehring, Bruno Oertel, Reinhard Sittl, Jörn Lötsch

Chronic opioid use is associated with increased DNA methylation correlating with increased clinical pain

2013, Pain

Jörn Lötsch, Carmen Walter, Michael J. Parnham, Bruno Oertel, Gerd Geisslinger

Pharmacokinetics of non-intravenous formulations of fentanyl

2013, Clinical Pharmacokinetics

Daniel Flesch, Manfred Schubert-Zsilavecz, Daniel Merk

Novel prostaglandin receptor modulators: a patent review (2002 - 2012) - part I: non-EP receptor modulators

2012, Expert opinion on therapeutic patents

Tilo Knape, Lisa K Eifler, Laura Kuchler, Bernhard Brüne, Michael J. Parnham, Andreas von Knethen

Kinetic characterization of selective persoxisome-proliferator-activated receptor gamma modulators in vitro

2012, BioMed Central

Estel la Buscato, Rene Blöcher, Franca-Maria Klingler, Steffen Hahn, Dieter Steinhilber, Manfred Schubert-Zsilavecz, Eugen Proschak

Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors

2012, Journal of medicinal chemistry

Bruno Oertel, Alexandra Doehring, Bianca Roskam, Mattias Kettner, Nadja Hackmann, Nerea Ferreiros, Peter H Schmidt, Jörn Lötsch

Genetic-epigenetic interaction modulates mu-opioid receptor regulation

2012, Human Molecular Genetics

Klaus Deckmann, Florian Rörsch, Gerd Geisslinger, Sabine Grösch

Dimethylcelecoxib induces an inhibitory complex consisting of HDAC1/NF-κB(p65)RelA leading to transcriptional downregulation of mPGES-1 and EGR1.

2012, Cellular Signalling

Annemarie Schreeb

Combination of Prototypical Histamine H3 and H4 Receptor Pharmacophores

2012, Inflammation Research

Dalial Freitak, Eileen Knorr, Heiko Vogel, Andreas Vilcinskas

Gender- and stressor-specific microRNA expression in Tribolium castaneum

2012, Biology Letters

Bona Linke, Yannick Schreiber, Dong Dong Zhang, Sandra Pierre, Ovidiu Coste, Marina Henke, Jing Suo, Judith Fuchs, Carlo Angioni, Nerea Ferreiros, Gerd Geisslinger, Klaus Scholich

Analysis of sphingolipid and prostaglandin synthesis during zymosan-induced inflammation

2012, Prostaglandins & Other Lipid Mediators

Krishnendu Krishnendu, Rainer Fischer, Andreas Vilcinskas

Histone acetylation mediates epigenetic regulation of transcriptional reprogramming in insects during metamorphosis, wounding and infection

2012, Frontiers in Zoology

Andreas Weigert, Benjamin Weichand, Divya Sekar, Weixiao Sha, Christina Dillmann, Javier Mora, Stephanie Ley, Silke Essler, Nathalie Dehne, Bernhard Brüne

HIF-1alpha is a negative regulator of plasmacytoid DC development in vitro and in vivo

2012, Blood

Michaela Jung, Andreas Weigert, Michaela Tausendschon, Javier Mora, Bilge Oren, Anna Sola, Georgina Hotter, Tatsushi Muta, Bernhard Brüne

Interleukin-10-induced neutrophil gelatinase-associated lipocalin production in macrophages with consequences for tumor growth

2012, Molecular and cellular biology

Miriam Tomasch, Johannes Stephan Schwed, Karina Kuczka, Sascha Meyer Dos Santos, Sebastian Harder, Rolf Nüsing, Alexander Paulke, Holger Stark

Fluorescent Human EP3 Receptor Antagonists

2012, ACS Medicinal Chemistry Letters

Daniel Junemann, Jennifer Dressman

Analytical methods for dissolution testing of nanosized drugs

2012, Journal of Pharmacy and Pharmacology

Divya Sekar, Christina Dillmann, Bernhard Brüne, Edward Roberts, Andreas Weigert

Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity

2012, European journal of immunology

Susanne Schiffmann, Nerea Ferreiros, Kerstin Birod, Max Eberle, Yannick Schreiber, Waltraud Pfeilschifter, Ulf Ziemann, Sandra Pierre, Klaus Scholich, Sabine Grösch, Gerd Geisslinger

Ceramide synthase 6 plays a critical role in the development of experimental autoimmune encephalomyelitis

2012, The Journal of Immunology

Sebastian Barzen, Carmen B. Rödl, Andreas Lill, Holger Stark, Bettina Hofmann

Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors

2012, Bioorganic & Medicinal Chemistry

Ramona Steri, Janosch Achenbach, Dieter Steinhilber, Manfred Schubert-Zsilavecz, Eugen Proschak

Investigation of imatinib and other approved drugs as starting points for antidiabetic drug discovery with FXR modulating activity

2012, Biochemical Pharmacology

Christine V. Möser, Katharina Kynast, Katharina Baatz, Otto Quintus Russe, Nerea Ferreiros, Heike Costiuk, Ruirui Lu, Achim Schmidtko, Irmgard Tegeder, Gerd Geisslinger, Ellen Niederberger

The protein kinase IKKepsilon is a potential target for the treatment of inflammatory hyperalgesia

2012, Journal of Immunology

Jessica Hoppstädter, Britta Diesel, Lisa Sha, Bernhard Brüne, Alexandra K. Kiemer

Glucocorticoid-induced leucine zipper is downregulated in human alveolar macrophages upon Toll-like receptor activation

2012, European journal of immunology

Klaus Deckmann, Florian Rörsch, Gerd Geisslinger, Sabine Grösch

Identification of DNA-protein complexes using an improved, combined western blotting-electrophoretic mobility shift assay (WEMSA) with a fluorescence imaging system.

2012, Royal Society of Chemistry

Melania Dovizio, Stefania Tacconelli, Emanuela Ricciotti, Annalisa Bruno, Thorsten Maier, Paola Anzellotti, Luigia Di Francesco, Paola Sala, Stefano Signoroni, Lucio Bertario, Dan A. Dixon, John A. Lawson, Dieter Steinhilber, Garret A. Fitzgerald, Paola Patrignani

Effects of celecoxib on prostanoid biosynthesis and circulating angiogenesis proteins in familial adenomatous polyposis.

2012, Journal of pharmacology and experimental therapeutics

Daniela Hartmann, Sina Fuchs, Jessica Lucks, Susanne Schiffmann, Yannick Schreiber, Nerea Ferreiros, Jennifer Merkens, Rolf Marschalek, Gerd Geisslinger, Sabine Grösch

Long chain ceramides and very long chain ceramides have opposite effects on human breast and colon cancer cell growth.

2012, The International Journal of Biochemistry & Cell Biology

Bettina Hofmann, Carmen B. Rödl, Astrid Stefanie Kahnt, Thorsten Maier, Angela A.Y. Michel, Marika Hoffmann, Oliver Rau, Khader Awwad, Maren Pellowska, Mario Wurglics, Matthias G. Wacker, Aleksandra Zivkovic, Ingrid Fleming, Manfred Schubert-Zsilavecz, Holger Stark, Gisbert Schneider, Dieter Steinhilber

Molecular pharmacological profile of a novel thiazolinone-based direct and selective 5-lipoxygenase inhibitor

2012, British Journal of Pharmacology

Jörn Lötsch, Gerd Geisslinger, Thomas Hummel

Sniffing out pharmacology: interactions of drugs with human olfaction

2012, Trends in Pharmacological Sciences

Florian Rörsch, Estel la Buscato, Klaus Deckmann, Gisbert Schneider, Manfred Schubert-Zsilavecz, Gerd Geisslinger, Eugen Proschak, Sabine Grösch

Structure-activity relationship of nonacidic quinazolinone inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1)

2012, Journal of Medicinal Chemistry

Martina Hieke, Carmen B. Rödl, Joanna M. Wisniewska, Holger Stark, Manfred Schubert-Zsilavecz, Dieter Steinhilber, Bettina Hofmann, Eugen Proschak

SAR-study on a new class of imidazo[1,2-a]pyridine-based inhibitors of 5-lipoxygenase

2012, Bioorganic & Medicinal Chemistry Letters

Michael Hornig, Stavroula Markoutsa, Ann-Kathrin Häfner, Sven George, Joanna M. Wisniewska, Carmen B. Rödl, Bettina Hofmann, Thorsten Maier, Michael Karas, Oliver Werz, Dieter Steinhilber

Inhibition of 5-lipoxygenase by U73122 is due to covalent binding to cysteine 416

2012, Biochimica et Biophysica Acta

Susanne Schiffmann, Daniela Hartmann, Sina Fuchs, Kerstin Birod, Nerea Ferreiros, Yannick Schreiber, Aleksandra Zivkovic, Gerd Geisslinger, Sabine Grösch, Holger Stark

Inhibitors of specific ceramide synthases

2012, Biochimie

Daniel Flesch, Manfred Schubert-Zsilavecz

Tumortherapeutika vor der Zulassung

2012, Pharmazeutische Zeitung

Sabine Grösch, Susanne Schiffmann, Gerd Geisslinger

Chain length-specific properties of ceramides

2012, Progress in Lipid Research

Tobias Schmid, Magdalena Bajer, Johanna Blees, Larissa Milke, Daniela Rubsamen, Kathrin Schulz, Andreas Weigert, Nancy Colburn, Bernhard Brüne