Autoren Details

Victor Hernandez-Olmos, Tilo Knape, Jan Heering, Andreas von Knethen, Whitney Kilu, Astrid Kaiser, Mario Wurglics, Moritz Helmstädter, Daniel Merk, Manfred Schubert-Zsilavecz, Michael J. Parnham, Dieter Steinhilber, Eugen Proschak

Structure optimization of a new class of PPARgamma antagonists

2019, Bioorganic & Medicinal Chemistry

Verene Trümper, Andreas von Knethen, Annegret Preuß, Eugeny Ermilov, Steffen Hackbarth, Laura Kuchler, Sandra Gunne (geb. Vomund), Anne Schäfer, Tobias Bornhütter, György Vereb, Lazlo Ujlaky-Nagy, Bernhard Brüne, Beate Röder, Michael Schindler, Michael J. Parnham, Tilo Knape

Flow cytometry-based FRET identifies binding intensities in PPARgamma1 protein-protein interactions in living cells

2019, Theranostics

Andreas von Knethen, Anne Schäfer, Laura Kuchler, Tilo Knape, Urs Christen, Edith Hintermann, Beate Fisslthaler, Katrin Schröder, Ralf Brandes, Berit Genz, Kerstin Abshagen, Brigitte M. Pützer, Lisa Sha, Andreas Weigert, Shahzad Nawaz Syed, Martin Schulz, Ajay M. Shah, Andreas Ernst, Mateusz Putyrski, Fabian Finkelmeier, Marina Pesic, Florian Greten, Michael Hogardt, Volkhard Kempf, Sandra Gunne (geb. Vomund), Michael J. Parnham, Bernhard Brüne

Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis.

2019, Theranostics

Verene Trümper, Andreas von Knethen, Annegret Preuß, Eugeny Ermilov, Steffen Hackbarth, Laura Kuchler, Sandra Gunne (geb. Vomund), Anne Schäfer, Tobias Bornhütter, György Vereb, Lazlo Ujlaky-Nagy, Bernhard Brüne, Beate Röder, Michael Schindler, Michael J. Parnham, Tilo Knape

Flow cytometry-based FRET identifies binding intensities in PPARγ1 protein-protein interactions in living cells

2019, Theranostics

Andreas von Knethen, Anne Schäfer, Laura Kuchler, Tilo Knape, Urs Christen, Edith Hintermann, Beate Fisslthaler, Katrin Schröder, Ralf Brandes, Berit Genz, Kerstin Abshagen, Brigitte M. Pützer, Lisa Sha, Andreas Weigert, Shahzad Nawaz Syed, Martin Schulz, Ajay M. Shah, Andreas Ernst, Mateusz Putyrski, Fabian Finkelmeier, Marina Pesic, Florian Greten, Michael Hogardt, Volkhard Kempf, Sandra Gunne (geb. Vomund), Michael J. Parnham, Bernhard Brüne

Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis

2019, Theranostics

Perihan A. Elzahhar, Rana Alaaddine, Tamer M. Ibrahim, Rasha Nassra, Azza Ismail, Benjamin S. K. Chua, Rebecca L. Frkic, John B. Bruning, Nadja Wallner, Tilo Knape, Andreas von Knethen, Hala Labib, Ahmed F. El-Yazbi, Ahmed S. F. Belal

Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones

2019, European Journal of Medicinal Chemistry

Laura Kuchler, Lisa Sha, Annika K Giegerich, Tilo Knape, Carlo Angioni, Nerea Ferreiros, Martina V. Schmidt, Andreas Weigert, Bernhard Brüne, Andreas von Knethen

Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis

2017, Molecular Immunology

Christoph Netzer, Tilo Knape, Laura Kuchler, Andreas Weigert, Kai Zacharowski, Waltraud Pfeilschifter, Gregory Sempowski, Michael J. Parnham, Bernhard Brüne, Andreas von Knethen

Apoptotic Diminution of Immature Single and Double Positive Thymocyte Subpopulations Contributes to Thymus Involution During Murine Polymicrobial Sepsis.

2017, Shock

Marco Brenneis, Ramin Aghajaanpour, Tilo Knape, Lisa Sha, Holger Neb, Patrick Meybohm, Kai Zacharowski, Ingeborg Hauser, Stefan Büttner, Michael J. Parnham, Bernhard Brüne, Andreas von Knethen

Ppargamma Expression in T Cells as a Prognostic Marker of Sepsis

2016, Shock

Marco Brenneis, Ramin Aghajaanpour, Tilo Knape, Lisa Sha, Holger Neb, Patrick Meybohm, Kai Zacharowski, Ingeborg Hauser, Stefan Büttner, Michael J. Parnham, Bernhard Brüne, Andreas von Knethen

Pparγ Expression in T Cells as a Prognostic Marker of Sepsis

2016, Shock

Tilo Knape, Daniel Flesch, Laura Kuchler, Lisa Sha, Annika K Giegerich, Sandra Labocha, Mario Wurglics, Manfred Schubert-Zsilavecz, Eugen Proschak, Bernhard Brüne, Michael J. Parnham, Andreas von Knethen

Identification and characterisation of a prototype for a new class of competitive PPARgamma antagonists

2015, European journal of pharmacology

Lisa Sha, Weixiao Sha, Laura Kuchler, Andreas Daiber, Annika K Giegerich, Andreas Weigert, Tilo Knape, Ryan Snodgrass, Katrin Schröder, Ralf Brandes, Bernhard Brüne, Andreas von Knethen

Loss of Nrf2 in bone marrow-derived macrophages impairs antigen-driven CD8(+) T cell function by limiting GSH and Cys availability

2015, Free radical biology & medicine

Andreas von Knethen, Lisa Sha, Tilo Knape, Laura Kuchler, Annika K Giegerich, Martin Schulz, Ingeborg Hauser, Bernhard Brüne

Activation of the peroxisome proliferator-activated receptor gamma counteracts sepsis-induced T cell cytotoxicity toward alloantigenic target cells

2015, Journal of Molecular Medicine

Laura Kuchler, Lisa Sha, Annika K Giegerich, Tilo Knape, Andreas Weigert, Bernhard Brüne, Andreas von Knethen

Sphingosine-1 phosphate promotes thymic atrophy during sepsis progression.

2014, Critical Care

Laura Kuchler, Annika K Giegerich, Lisa Sha, Tilo Knape, Michael Wong, Katrin Schröder, Ralf Brandes, Heinrich Heide, Ilka Wittig, Bernhard Brüne, Andreas von Knethen

SYNCRIP-Dependent Nox2 mRNA Destabilization Impairs ROS Formation in M2-Polarized Macrophages

2014, Antioxidants & redox signaling

Annika K Giegerich, Laura Kuchler, Lisa Sha, Tilo Knape, Heinrich Heide, Ilka Wittig, Christian Behrends, Bernhard Brüne, Andreas von Knethen

Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression

2014, Autophagy

Tilo Knape, Lisa Sha, Laura Kuchler, Bernhard Brüne, Michael J. Parnham, Andreas von Knethen

Kinetic characterization of selective persoxisome-proliferator-activated receptor gamma modulators in vitro

2012, BioMed Central

Dr. Tilo Knape

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