Autoren Details

Contact Info

Fraunhofer IME
Projektgruppe Translationale Medizin und Pharmakologie TMP
Theodor-Stern-Kai 7
60596 Frankfurt

E-Mail: susanne.schiffmann@ime.fraunhofer.de

Publizierte Papers

Leonard Blum, Gerd Geisslinger, Michael J. Parnham, Arnold Grünweller, Susanne Schiffmann

Natural antiviral compound silvestrol modulates human monocyte‐derived macrophages and dendritic cells

2020, Journal of Cellular and Molecular Medicine

Leonard Blum, Sheraz Gul, Thomas Ulshöfer, Marina Henke, Reimar Krieg, Isabell Berneburg, Dominique Thomas, Sandra Trautmann, Jennifer Kurz, Joachim Geyer, Gerd Geisslinger, Katja Becker, Michael J. Parnham, Susanne Schiffmann

In-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o

2020, Scientific Reports

Sarah Bazarganipour, Johannes Hausmann, Stephanie Oertel, Khadija El-Hindi, Sebastian Brachtendorf, Irina Blumenstein, Alica Kubesch, Kathrin Sprinzl, Kerstin Birod, Lisa Hahnefeld, Sandra Trautmann, Dominique Thomas, Eva Hermann, Gerd Geisslinger, Susanne Schiffmann, Sabine Grösch

The Lipid Status in Patients with Ulcerative Colitis: Sphingolipids are Disease-Dependent Regulated.

2019, Journal of Clinical Medicine

Jennifer Kurz, Julia Barthelmes, Leonard Blum, Thomas Ulshöfer, Marthe-Susanna Wegner, Nerea Ferreiros, Luise Roser, Gerd Geisslinger, Sabine Grösch, Susanne Schiffmann

Role of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes.

2019, Scientific Reports

Sorwe Mojtahed Poor, Thomas Ulshöfer, Laureen Gabriel, Marina Henke, Michaela Köhm, Frank Behrens, Gerd Geisslinger, Michael J. Parnham, Harald Burkhardt, Susanne Schiffmann

Immunogenicity assay development and validation for biologic therapy as exemplified by ustekinumab

2019, Clinical & Experimental Immunology

Tivadar Feczkó, Albrecht Piiper, Saema Ansar, Frank W. Blixt, Mukul Ashtikar, Susanne Schiffmann, Thomas Ulshöfer, Michael J. Parnham, Yifat Harel, Liron Limor Israel, Jean-Paul Lellouche, Matthias G. Wacker

Stimulating brain recovery after stroke using theranostic albumin nanocarriers loaded with nerve growth factor in combination therapy.

2018, Journal of Controlled Release

Jennifer Kurz, Michael J. Parnham, Gerd Geisslinger, Susanne Schiffmann

Ceramides as Novel Disease Biomarkers.

2018, Trends in Molecular Medicine

Jörn Lötsch, Susanne Schiffmann, Katja Schmitz, Robert Brunkhorst, Florian Lerch, Nerea Ferreiros, Sabine Wicker, Irmgard Tegeder, Gerd Geisslinger, Alfred Ultsch

Machine-learning based lipid mediator serum concentration patterns allow identification of multiple sclerosis patients with high accuracy

2018, Scientific Reports

Leonard Blum, Susanne Schiffmann, Michael J. Parnham

Immunomodulation by antibiotics

2018, Fighting Antimicrobial Resistance (IAPC Book)

Leonard Blum, Nadja Tafferner, Ilknur Spring, Jennifer Kurz, Natasja de Bruin, Gerd Geisslinger, Michael J. Parnham, Susanne Schiffmann

Dietary phytol reduces clinical symptoms in experimental autoimmune encephalomyelitis (EAE) at least partially by modulating NOX2 expression.

2018, Journal of Molecular Medicine

Jennifer Kurz, Robert Brunkhorst, Christian Förch, Leonard Blum, Marina Henke, Laureen Gabriel, Thomas Ulshöfer, Nerea Ferreiros, Michael J. Parnham, Gerd Geisslinger, Susanne Schiffmann

The relevance of ceramides and their synthesizing enzymes for multiple sclerosis

2018, Clinical Science

Jörn Lötsch, Alfred Ultsch, Susanne Schiffmann, Irmgard Tegeder, Nerea Ferreiros, Sabine Wicker, Gerd Geisslinger

Machine-learned lipid marker serum concentration based biomarker identifies multiple sclerosis patients at high accuracy

2017, Neurology

Jörn Lötsch, Michael Thrun, Florian Lerch, Robert Brunkhorst, Susanne Schiffmann, Dominique Thomas, Irmgard Tegeder, Gerd Geisslinger, Alfred Ultsch

Machine-Learned Data Structures of Lipid Marker Serum Concentrations in Multiple Sclerosis Patients Differ from Those in Healthy Subjects.

2017, Internation Journal of Molecular Sciences

Katja Schmitz, Robert Brunkhorst, Natasja de Bruin, Christoph Mayer, Annett Wilken-Schmitz, Nerea Ferreiros, Susanne Schiffmann, Michael J. Parnham, Sorin Tunaru, Jerold Chun, Stefan Offermanns, Christian Förch, Klaus Scholich, Johannes Vogt, Sabine Wicker, Jörn Lötsch, Gerd Geisslinger, Irmgard Tegeder

Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis

2017, Acta Neuropathologica Communications

Marthe-Susanna Wegner, Susanne Schiffmann, Michael J. Parnham, Gerd Geisslinger, Sabine Grösch

The enigma of ceramide synthase regulation in mammalian cells

2016, Progress in Lipid Research

Julia Barthelmes, Nadja Tafferner, Jennifer Kurz, Natasja de Bruin, Michael J. Parnham, Gerd Geisslinger, Susanne Schiffmann

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

2016, Journal of visualized experiments

Natasja de Bruin, Katja Schmitz, Susanne Schiffmann, Nadja Tafferner, Mike Schmidt, Holger Jordan, Annett Wilken-Schmitz, Irmgard Tegeder, Gerd Geisslinger, Michael J. Parnham

Multiple rodent models and behavioral measures reveal unexpected responses to FTY720 and DMF in experimental autoimmune encephalomyelitis

2016, Behavioural brain research

Nadja Tafferner, Julia Barthelmes, Max Eberle, Thomas Ulshöfer, Marina Henke, Natasja de Bruin, Christoph Mayer, Christian Förch, Gerd Geisslinger, Michael J. Parnham, Susanne Schiffmann

Alpha-methylacyl-CoA racemase deletion has mutually counteracting effects on T-cell responses, associated with unchanged course of EAE

2016, European journal of immunology

Christoph Mayer, Nadja Tafferner, Julia Barthelmes, Max Eberle, Nerea Ferreiros, Thomas Ulshöfer, Marina Henke, Natasja de Bruin, Gerd Geisslinger, Christian Förch, Michael J. Parnham, Susanne Schiffmann

Different pathophysiological relevance of branched fatty acid metabolism in mice and men: alpha-methylacyl-CoA racemase regulates the T cell response only in experimental autoimmune encephalomyelitis but not in multiple sclerosis

2015, Multiple Sclerosis Journal

Christoph Mayer, Anika Männer de Bazo, Christian Förch, Max Eberle, Philipp Ebel, Julia Barthelmes, Nadja Tafferner, Nerea Ferreiros, Thomas Ulshöfer, Marina Henke, Sabine Grösch, Gerd Geisslinger, Klaus Willecke, Susanne Schiffmann

Ceramide synthase6 / C16-ceramides mediate anti-inflammatory effects during the development of EAE and MS possibly by suppressing the migration and by deactivation of neutrophils: a new target for anti-inflammatory therapy in MS?

2015, Multiple Sclerosis Journal

Monica Villa Nova, Christine Janas, Mike Schmidt, Thomas Ulshöfer, Susanna Grafe, Susanne Schiffmann, Natasja de Bruin, Arno Wiehe, Volker Albrecht, Michael J. Parnham, Marcos Luciano Bruschi, Matthias G. Wacker

Nanocarriers for photodynamic therapy-rational formulation design and medium-scale manufacture

2015, International journal of pharmaceutics

Julia Barthelmes, Anika Männer de Bazo, Yael Pewzner-Jung, Katja Schmitz, Christoph Mayer, Christian Förch, Max Eberle, Nadja Tafferner, Nerea Ferreiros, Marina Henke, Gerd Geisslinger, Anthony Futerman, Sabine Grösch, Susanne Schiffmann

Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils

2015, Brain, behavior, and immunity

Max Eberle, Philipp Ebel, Christoph Mayer, Julia Barthelmes, Nadja Tafferner, Nerea Ferreiros, Thomas Ulshöfer, Marina Henke, Christian Förch, Anika Männer de Bazo, Sabine Grösch, Gerd Geisslinger, Klaus Willecke, Susanne Schiffmann

Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils

2015, Immunology and cell biology

Max Eberle, Philipp Ebel, Marthe-Susanna Wegner, Julia Barthelmes, Nadja Tafferner, Nerea Ferreiros, Kerstin Birod, Yannick Schreiber, Gurumoorthy Krishnamoorthy, Klaus Willecke, Gerd Geisslinger, Sabine Grösch, Susanne Schiffmann

Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent

2014, Biochemical pharmacology

Susanne Schiffmann, Andreas Weigert, Julia Barthelmes, Max Eberle, Kerstin Birod, Annett Wilken-Schmitz, Nerea Ferreiros, Yannick Schreiber, Manuel Grez, Benjamin Weichand, Bernhard Brüne, Waltraud Pfeilschifter, Rolf Nüsing, Ellen Niederberger, Sabine Grösch, Klaus Scholich, Gerd Geisslinger

PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis

2014, Biochemical pharmacology

Dominique Thomas, Max Eberle, Susanne Schiffmann, Dong Dong Zhang, Gerd Geisslinger, Nerea Ferreiros

Nano-LC-MS/MS for the quantitation of ceramides in mice cerebrospinal fluid using minimal sample volume

2013, Talanta

Susanne Schiffmann, Kerstin Birod, Julia Barthelmes, Max Eberle, Marthe-Susanna Wegner, Ruth Wanger, Daniela Hartmann, Nerea Ferreiros, Gerd Geisslinger, Sabine Grösch

Ceramide metabolism in mouse tissue

2013, The international journal of biochemistry & cell biology

Daniela Hartmann, Marthe-Susanna Wegner, Nerea Ferreiros, Yannick Schreiber, Jessica Lucks, Susanne Schiffmann, Gerd Geisslinger, Sabine Grösch

The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS

2013, The International Journal of Biochemistry & Cell Biology

Susanne Schiffmann, Nerea Ferreiros, Kerstin Birod, Max Eberle, Yannick Schreiber, Waltraud Pfeilschifter, Ulf Ziemann, Sandra Pierre, Klaus Scholich, Sabine Grösch, Gerd Geisslinger

Ceramide synthase 6 plays a critical role in the development of experimental autoimmune encephalomyelitis

2012, The Journal of Immunology

Daniela Hartmann, Sina Fuchs, Jessica Lucks, Susanne Schiffmann, Yannick Schreiber, Nerea Ferreiros, Jennifer Merkens, Rolf Marschalek, Gerd Geisslinger, Sabine Grösch

Long chain ceramides and very long chain ceramides have opposite effects on human breast and colon cancer cell growth.

2012, The International Journal of Biochemistry & Cell Biology

Susanne Schiffmann, Daniela Hartmann, Sina Fuchs, Kerstin Birod, Nerea Ferreiros, Yannick Schreiber, Aleksandra Zivkovic, Gerd Geisslinger, Sabine Grösch, Holger Stark

Inhibitors of specific ceramide synthases

2012, Biochimie

Sabine Grösch, Susanne Schiffmann, Gerd Geisslinger

Chain length-specific properties of ceramides

2012, Progress in Lipid Research