Autoren Details

Leonard Blum, Gerd Geisslinger, Michael J. Parnham, Arnold Grünweller, Susanne Schiffmann

Natural antiviral compound silvestrol modulates human monocyte‐derived macrophages and dendritic cells

2020, Journal of Cellular and Molecular Medicine

Leonard Blum, Sheraz Gul, Thomas Ulshöfer, Marina Henke, Reimar Krieg, Isabell Berneburg, Dominique Thomas, Sandra Trautmann, Jennifer Kurz, Joachim Geyer, Gerd Geisslinger, Katja Becker, Michael J. Parnham, Susanne Schiffmann

In-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o

2020, Scientific Reports

Michael J. Parnham, Gerd Geisslinger

Pharmacological plasticity-How do you hit a moving target?

2019, Pharmacology Research & Perspectives

Victor Hernandez-Olmos, Tilo Knape, Jan Heering, Andreas von Knethen, Whitney Kilu, Astrid Kaiser, Mario Wurglics, Moritz Helmstädter, Daniel Merk, Manfred Schubert-Zsilavecz, Michael J. Parnham, Dieter Steinhilber, Eugen Proschak

Structure optimization of a new class of PPARgamma antagonists

2019, Bioorganic & Medicinal Chemistry

Verene Trümper, Andreas von Knethen, Annegret Preuß, Eugeny Ermilov, Steffen Hackbarth, Laura Kuchler, Sandra Gunne (geb. Vomund), Anne Schäfer, Tobias Bornhütter, György Vereb, Lazlo Ujlaky-Nagy, Bernhard Brüne, Beate Röder, Michael Schindler, Michael J. Parnham, Tilo Knape

Flow cytometry-based FRET identifies binding intensities in PPARgamma1 protein-protein interactions in living cells

2019, Theranostics

Ellen Niederberger, Michael J. Parnham, Maas Maas, Gerd Geisslinger

4 Ds in health research-working together toward rapid precision medicine.

2019, EMBO Molecular Medicine

Yingying Han, Javier Mora, Arnaud Huard, Priscila da Silva, Svenja Wiechmann, Mateusz Putyrski, Christian Schuster, Eiman Elwakeel, Guangping Lang, Anica Scholz, Tobias Schmid, Natasja de Bruin, Pierre Billuart, Carlo Sala, Harald Burkhardt, Michael J. Parnham, Andreas Ernst, Bernhard Brüne, Andreas Weigert

IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells.

2019, Cell Reports

Andreas von Knethen, Anne Schäfer, Laura Kuchler, Tilo Knape, Urs Christen, Edith Hintermann, Beate Fisslthaler, Katrin Schröder, Ralf Brandes, Berit Genz, Kerstin Abshagen, Brigitte M. Pützer, Lisa Sha, Andreas Weigert, Shahzad Nawaz Syed, Martin Schulz, Ajay M. Shah, Andreas Ernst, Mateusz Putyrski, Fabian Finkelmeier, Marina Pesic, Florian Greten, Michael Hogardt, Volkhard Kempf, Sandra Gunne (geb. Vomund), Michael J. Parnham, Bernhard Brüne

Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis.

2019, Theranostics

Verene Trümper, Andreas von Knethen, Annegret Preuß, Eugeny Ermilov, Steffen Hackbarth, Laura Kuchler, Sandra Gunne (geb. Vomund), Anne Schäfer, Tobias Bornhütter, György Vereb, Lazlo Ujlaky-Nagy, Bernhard Brüne, Beate Röder, Michael Schindler, Michael J. Parnham, Tilo Knape

Flow cytometry-based FRET identifies binding intensities in PPARγ1 protein-protein interactions in living cells

2019, Theranostics

Andreas von Knethen, Anne Schäfer, Laura Kuchler, Tilo Knape, Urs Christen, Edith Hintermann, Beate Fisslthaler, Katrin Schröder, Ralf Brandes, Berit Genz, Kerstin Abshagen, Brigitte M. Pützer, Lisa Sha, Andreas Weigert, Shahzad Nawaz Syed, Martin Schulz, Ajay M. Shah, Andreas Ernst, Mateusz Putyrski, Fabian Finkelmeier, Marina Pesic, Florian Greten, Michael Hogardt, Volkhard Kempf, Sandra Gunne (geb. Vomund), Michael J. Parnham, Bernhard Brüne

Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis

2019, Theranostics

Marco Sisignano, Michael J. Parnham, Gerd Geisslinger

Novel Approaches to Persistent Pain Therapy

2019, Trends in Pharmacological Sciences

Marco Sisignano, Jörn Lötsch, Michael J. Parnham, Gerd Geisslinger

Potential biomarkers for persistent and neuropathic pain therapy.

2019, Pharmacology & Therapeutics

Sorwe Mojtahed Poor, Thomas Ulshöfer, Laureen Gabriel, Marina Henke, Michaela Köhm, Frank Behrens, Gerd Geisslinger, Michael J. Parnham, Harald Burkhardt, Susanne Schiffmann

Immunogenicity assay development and validation for biologic therapy as exemplified by ustekinumab

2019, Clinical & Experimental Immunology

Tivadar Feczkó, Albrecht Piiper, Saema Ansar, Frank W. Blixt, Mukul Ashtikar, Susanne Schiffmann, Thomas Ulshöfer, Michael J. Parnham, Yifat Harel, Liron Limor Israel, Jean-Paul Lellouche, Matthias G. Wacker

Stimulating brain recovery after stroke using theranostic albumin nanocarriers loaded with nerve growth factor in combination therapy.

2018, Journal of Controlled Release

Jennifer Kurz, Michael J. Parnham, Gerd Geisslinger, Susanne Schiffmann

Ceramides as Novel Disease Biomarkers.

2018, Trends in Molecular Medicine

Lisa Nothnagel, Fabian Jung, Tanja Rossmanith, Manuela Thurn, Mukul Ashtikar, Gerd Geisslinger, Michael J. Parnham, Matthias G. Wacker

Predictive PBPK modeling as a tool in the formulation of the drug candidate TMP-001.

2018, European Journal of Pharmaceutics and Biopharmaceutics

Dario Kringel, Catharina Lippmann, Michael J. Parnham, Eija Kalso, Alfred Ultsch, Jörn Lötsch

A machine-learned analysis of human gene polymorphisms modulating persisting pain points to major roles of neuroimmune processes.

2018, European Journal of Pain

Leonard Blum, Susanne Schiffmann, Michael J. Parnham

Immunomodulation by antibiotics

2018, Fighting Antimicrobial Resistance (IAPC Book)

Leonard Blum, Nadja Tafferner, Ilknur Spring, Jennifer Kurz, Natasja de Bruin, Gerd Geisslinger, Michael J. Parnham, Susanne Schiffmann

Dietary phytol reduces clinical symptoms in experimental autoimmune encephalomyelitis (EAE) at least partially by modulating NOX2 expression.

2018, Journal of Molecular Medicine

Jennifer Kurz, Robert Brunkhorst, Christian Förch, Leonard Blum, Marina Henke, Laureen Gabriel, Thomas Ulshöfer, Nerea Ferreiros, Michael J. Parnham, Gerd Geisslinger, Susanne Schiffmann

The relevance of ceramides and their synthesizing enzymes for multiple sclerosis

2018, Clinical Science

Hiromi Shiratori, Carmen Feinweber, Sonja Luckhardt, Nadja Wallner, Gerd Geisslinger, Andreas Weigert, Michael J. Parnham

An in vitro test system for compounds that modulate human inflammatory macrophage polarization

2018, European Journal of Pharmacology

Martine Hofmann, Mike Schmidt, Olga Arne, Gerd Geisslinger, Michael J. Parnham, Natasja de Bruin

Non-invasive bioluminescence imaging as a standardized assessment measure in mouse models of dermal inflammation

2018, Journal of Dermatological Science

Natasja de Bruin, Nerea Ferreiros, Mike Schmidt, Martine Hofmann, Carlo Angioni, Gerd Geisslinger, Michael J. Parnham

Mutual inversion of flurbiprofen enantiomers in various rat and mouse strains

2018, Chirality

Sandra Gunne (geb. Vomund), Anne Schäfer, Michael J. Parnham, Bernhard Brüne, Andreas von Knethen

Nrf2, the Master Regulator of Anti-Oxidative Responses

2017, International Journal of Molecular Sciences

Michael J. Parnham

Progress does not just come in giant leaps: adapting techniques for the study of inflammation to novel applications

2017, Inflammation Research

Katja Schmitz, Robert Brunkhorst, Natasja de Bruin, Christoph Mayer, Annett Wilken-Schmitz, Nerea Ferreiros, Susanne Schiffmann, Michael J. Parnham, Sorin Tunaru, Jerold Chun, Stefan Offermanns, Christian Förch, Klaus Scholich, Johannes Vogt, Sabine Wicker, Jörn Lötsch, Gerd Geisslinger, Irmgard Tegeder

Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis

2017, Acta Neuropathologica Communications

Christoph Netzer, Tilo Knape, Laura Kuchler, Andreas Weigert, Kai Zacharowski, Waltraud Pfeilschifter, Gregory Sempowski, Michael J. Parnham, Bernhard Brüne, Andreas von Knethen

Apoptotic Diminution of Immature Single and Double Positive Thymocyte Subpopulations Contributes to Thymus Involution During Murine Polymicrobial Sepsis.

2017, Shock

Jessica Roos, Marcus Peters, Isabelle Maucher, Benjamin Kühn, Jasmin Fettel, Nadine Hellmuth, Camilla Brat, Benita Sommer, Anja Urbschat, Matthias Piesche, Anja Vogel, Eugen Proschak, Rene Blöcher, Estel la Buscato, Ann-Kathrin Häfner, Carmela Matrone, Oliver Werz, Juliana Heidler, Bianca M. Wittig, Carlo Angioni, Gerd Geisslinger, Michael J. Parnham, Kai Zacharowski, Dieter Steinhilber, Thorsten Maier

Drug-mediated intracellular donation of nitric oxide potently inhibits 5-lipoxygenase: a possible key to future anti-leukotriene therapy

2017, Antioxidants & redox signaling

Hiromi Shiratori, Carmen Feinweber, Sonja Luckhardt, Bona Linke, Eduard Resch, Gerd Geisslinger, Andreas Weigert, Michael J. Parnham

THP-1 and human peripheral blood mononuclear cell-derived macrophages differ in their capacity to polarize in vitro

2017, Molecular Immunology

Ellen Niederberger, Eduard Resch, Michael J. Parnham, Gerd Geisslinger

Drugging the pain epigenome

2017, Nature Reviews Neurology

Isabelle Maucher, Michael Rühl, Simon Kretschmer, Bettina Hofmann, Benjamin Kühn, Jasmin Fettel, Anja Vogel, Karsten T. Flügel, Georg Manolikakes, Nadine Hellmuth, Ann-Kathrin Häfner, Vahid Golghalyani, Ann-Katrin Ball, Matthias Piesche, Carmela Matrone, Gerd Geisslinger, Michael J. Parnham, Michael Karas, Dieter Steinhilber, Jessica Roos, Thorsten Maier

Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418

2017, Biochemical Pharmacology

Hiromi Shiratori, Carmen Feinweber, Claudia Knothe, Jörn Lötsch, Dominique Thomas, Gerd Geisslinger, Michael J. Parnham, Eduard Resch

High-Throughput Analysis of Global DNA Methylation Using Methyl-Sensitive Digestion

2016, PloS one

Marco Sisignano, Carlo Angioni, Chul-Kyu Park, Sascha Meyer Dos Santos, Holger Jordan, Maria Kuzikov, Di Liu, Sebastian Zinn, Stephan Hohmann, Yannick Schreiber, Bela Zimmer, Mike Schmidt, Ruirui Lu, Jing Suo, Dong Dong Zhang, Stephan M. G. Schäfer, Martine Hofmann, Ajay S. Yekkirala, Natasja de Bruin, Michael J. Parnham, Clifford J. Woolf, Ru-Rong Ji, Klaus Scholich, Gerd Geisslinger

Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain

2016, Proceedings of the National Academy of Sciences

Marco Brenneis, Ramin Aghajaanpour, Tilo Knape, Lisa Sha, Holger Neb, Patrick Meybohm, Kai Zacharowski, Ingeborg Hauser, Stefan Büttner, Michael J. Parnham, Bernhard Brüne, Andreas von Knethen

Pparγ Expression in T Cells as a Prognostic Marker of Sepsis

2016, Shock

Marco Brenneis, Ramin Aghajaanpour, Tilo Knape, Lisa Sha, Holger Neb, Patrick Meybohm, Kai Zacharowski, Ingeborg Hauser, Stefan Büttner, Michael J. Parnham, Bernhard Brüne, Andreas von Knethen

Ppargamma Expression in T Cells as a Prognostic Marker of Sepsis

2016, Shock

Marthe-Susanna Wegner, Susanne Schiffmann, Michael J. Parnham, Gerd Geisslinger, Sabine Grösch

The enigma of ceramide synthase regulation in mammalian cells

2016, Progress in Lipid Research

Susanne Beyer, Li Xie, Mike Schmidt, Natasja de Bruin, Mukul Ashtikar, Sabrina Ruschenbaum, Christian Lange, Vitali Vogel, Werner Mantele, Michael J. Parnham, Matthias G. Wacker

Optimizing novel implant formulations for the prolonged release of biopharmaceuticals using in vitro and in vivo imaging techniques

2016, Journal of Controlled Release

Julia Barthelmes, Nadja Tafferner, Jennifer Kurz, Natasja de Bruin, Michael J. Parnham, Gerd Geisslinger, Susanne Schiffmann

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

2016, Journal of visualized experiments

Marco Sisignano, Michael J. Parnham, Gerd Geisslinger

Drug Repurposing for the Development of Novel Analgesics

2016, Trends in pharmacological sciences

Natasja de Bruin, Katja Schmitz, Susanne Schiffmann, Nadja Tafferner, Mike Schmidt, Holger Jordan, Annett Wilken-Schmitz, Irmgard Tegeder, Gerd Geisslinger, Michael J. Parnham

Multiple rodent models and behavioral measures reveal unexpected responses to FTY720 and DMF in experimental autoimmune encephalomyelitis

2016, Behavioural brain research

Nadja Tafferner, Julia Barthelmes, Max Eberle, Thomas Ulshöfer, Marina Henke, Natasja de Bruin, Christoph Mayer, Christian Förch, Gerd Geisslinger, Michael J. Parnham, Susanne Schiffmann

Alpha-methylacyl-CoA racemase deletion has mutually counteracting effects on T-cell responses, associated with unchanged course of EAE

2016, European journal of immunology

Jessica Roos, Sabine Grösch, Oliver Werz, Peter Schröder, Slava Ziegler, Simone Fulda, Patrick Paulus, Anja Urbschat, Benjamin Kühn, Isabelle Maucher, Jasmin Fettel, Thomas Vorup-Jensen, Matthias Piesche, Carmela Matrone, Dieter Steinhilber, Michael J. Parnham, Thorsten Maier

Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?

2016, Pharmacology & therapeutics

Christoph Lehmann, Julia Homann, Ann-Katrin Ball, Rene Blöcher, Thea K Kleinschmidt, Devaraj Basavarajappa, Nerea Ferreiros, Ann-Kathrin Häfner, Olof Radmark, Jesper Z. Haeggstrom, Gerd Geisslinger, Michael J. Parnham, Dieter Steinhilber, Astrid Stefanie Kahnt

Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein

2015, FASEB Journal

Christoph Mayer, Nadja Tafferner, Julia Barthelmes, Max Eberle, Nerea Ferreiros, Thomas Ulshöfer, Marina Henke, Natasja de Bruin, Gerd Geisslinger, Christian Förch, Michael J. Parnham, Susanne Schiffmann

Different pathophysiological relevance of branched fatty acid metabolism in mice and men: alpha-methylacyl-CoA racemase regulates the T cell response only in experimental autoimmune encephalomyelitis but not in multiple sclerosis

2015, Multiple Sclerosis Journal

Monica Villa Nova, Christine Janas, Mike Schmidt, Thomas Ulshöfer, Susanna Grafe, Susanne Schiffmann, Natasja de Bruin, Arno Wiehe, Volker Albrecht, Michael J. Parnham, Marcos Luciano Bruschi, Matthias G. Wacker

Nanocarriers for photodynamic therapy-rational formulation design and medium-scale manufacture

2015, International journal of pharmaceutics

Susanne Beyer, Aline Moosmann, Astrid Stefanie Kahnt, Thomas Ulshöfer, Michael J. Parnham, Nerea Ferreiros, Sylvia Wagner, Matthias G. Wacker

Drug Release and Targeting: the Versatility of Polymethacrylate Nanoparticles for Peroral Administration Revealed by Using an Optimized In Vitro-Toolbox

2015, Pharmaceutical research

Carmen Walter, Violeta Dimova, Julia Bu, Michael J. Parnham, Bruno Oertel, Jörn Lötsch

Inverted Perceptual Judgment of Nociceptive Stimuli at Threshold Level following Inconsistent Cues

2015, PLoS One

Tilo Knape, Daniel Flesch, Laura Kuchler, Lisa Sha, Annika K Giegerich, Sandra Labocha, Mario Wurglics, Manfred Schubert-Zsilavecz, Eugen Proschak, Bernhard Brüne, Michael J. Parnham, Andreas von Knethen

Identification and characterisation of a prototype for a new class of competitive PPARgamma antagonists

2015, European journal of pharmacology

Julia Homann, Christoph Lehmann, Astrid Stefanie Kahnt, Dieter Steinhilber, Michael J. Parnham, Gerd Geisslinger, Nerea Ferreiros