Autoren Details

Jan Vollert, Walter Magerl, Ralf Baron, Andreas Binder, Elena K. Enax-Krumova, Gerd Geisslinger, Janne Gierthmühlen, Florian Henrich, Philipp Hüllemann, Thomas Klein, Jörn Lötsch, Christoph Maier, Bruno Oertel, Sigrid Schuh-Hofer, Thomas R. Tölle, Rolf-Detlef Treede

Pathophysiological mechanisms of neuropathic pain: comparison of sensory phenotypes in patients and human surrogate pain models

2018, Pain

Catharina Lippmann, Dario Kringel, Alfred Ultsch, Jörn Lötsch

Computational functional genomics-based approaches in analgesic drug discovery and repurposing

2018, Pharmacogenomics

Iris Weyer-Menkhoff, Michael Thrun, Jörn Lötsch

Machine-learned analysis of quantitative sensory testing responses to noxious cold stimulation in healthy subjects

2018, European Journal of Pain

Dario Kringel, Gerd Geisslinger, Eduard Resch, Bruno Oertel, Michael Thrun, Sarah Heinemann, Jörn Lötsch

Machine-learned analysis of the association of next-generation sequencing-based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin

2018, Pain

Jörn Lötsch, Alfred Ultsch

Machine learning in pain research

2017, Pain

Carmen Walter, Bruno Oertel, Lisa Felden, Ulrike Noth, Johannes Vermehren, Ralf Deichmann, Jörn Lötsch

Effects of oral Δ9-tetrahydrocannabinol on the cerebral processing of olfactory input in healthy non-addicted subjects.

2017, European Journal of Clinical Pharmacology

Violeta Dimova, Bruno Oertel, Jörn Lötsch

Using a Standardized Clinical Quantitative Sensory Testing Battery to Judge the Clinical Relevance of Sensory Differences Between Adjacent Body Areas

2017, The Clinical Journal of Pain

Dario Kringel, Marco Sisignano, Sebastian Zinn, Jörn Lötsch

Next-generation sequencing of the human TRPV1 gene and the regulating co-players LTB4R and LTB4R2 based on a custom AmpliSeq panel

2017, PLoS One

Jörn Lötsch, Alfred Ultsch, Susanne Schiffmann, Irmgard Tegeder, Nerea Ferreiros, Sabine Wicker, Gerd Geisslinger

Machine-learned lipid marker serum concentration based biomarker identifies multiple sclerosis patients at high accuracy

2017, Neurology

Jörn Lötsch, Catharina Lippmann, Dario Kringel, Alfred Ultsch

Integrated Computational Analysis of Genes Associated with Human Hereditary Insensitivity to Pain. A Drug Repurposing Perspective

2017, Frontiers in Molecular Neuroscience

Jörn Lötsch, Alfred Ultsch, Eija Kalso

Prediction of persistent post-surgery pain by preoperative cold pain sensitivity: biomarker development with machine-learning-derived analysis

2017, British Journal of Anaesthesia

Jörn Lötsch, Gerd Geisslinger, Sarah Heinemann, Florian Lerch, Bruno Oertel, Alfred Ultsch

Quantitative sensory testing response patterns to capsaicin- and ultraviolet-B-induced local skin hypersensitization in healthy subjects: a machine-learned analysis

2017, Pain

Jörn Lötsch, Michael Thrun, Florian Lerch, Robert Brunkhorst, Susanne Schiffmann, Dominique Thomas, Irmgard Tegeder, Gerd Geisslinger, Alfred Ultsch

Machine-Learned Data Structures of Lipid Marker Serum Concentrations in Multiple Sclerosis Patients Differ from Those in Healthy Subjects.

2017, Internation Journal of Molecular Sciences

Alfred Ultsch, Jörn Lötsch

Machine-learned cluster identification in high-dimensional data

2017, Journal of Biomedical Informatics

Katja Schmitz, Robert Brunkhorst, Natasja de Bruin, Christoph Mayer, Annett Wilken-Schmitz, Nerea Ferreiros, Susanne Schiffmann, Michael J. Parnham, Sorin Tunaru, Jerold Chun, Stefan Offermanns, Christian Förch, Klaus Scholich, Johannes Vogt, Sabine Wicker, Jörn Lötsch, Gerd Geisslinger, Irmgard Tegeder

Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis

2017, Acta Neuropathologica Communications

Alfred Ultsch, Jörn Lötsch

A data science based standardized Gini index as a Lorenz dominance preserving measure of the inequality of distributions

2017, PLoS One

Hiromi Shiratori, Carmen Feinweber, Claudia Knothe, Jörn Lötsch, Dominique Thomas, Gerd Geisslinger, Michael J. Parnham, Eduard Resch

High-Throughput Analysis of Global DNA Methylation Using Methyl-Sensitive Digestion

2016, PloS one

Alfred Ultsch, Dario Kringel, Eija Kalso, Jeffrey S. Mogil, Jörn Lötsch

A data science approach to candidate gene selection of pain regarded as a process of learning and neural plasticity

2016, Pain

Jörn Lötsch, Alfred Ultsch, Thomas Hummel

How Many and Which Odor Identification Items Are Needed to Establish Normal Olfactory Function?

2016, Chemical Senses

Jörn Lötsch, Alfred Ultsch, Thomas Hummel

A Unifying Data-Driven Model of Human Olfactory Pathology Representing Known Etiologies of Dysfunction

2016, Chemical Senses

Dario Kringel, Jörn Lötsch

Next-generation sequencing of human opioid receptor genes based on a custom AmpliSeq library and ion torrent personal genome machine

2016, Clinica Chimica Acta

Jörn Lötsch, Antje Hahner, Gudrun Gossrau, Cornelia Hummel, Carmen Walter, Alfred Ultsch, Thomas Hummel

Smell of pain: intersection of nociception and olfaction

2016, Pain

Jörn Lötsch, Thomas Hummel, Alfred Ultsch

Machine-learned pattern identification in olfactory subtest results

2016, Scientific Reports

Jörn Lötsch, Alfred Ultsch

Process Pharmacology: A Pharmacological Data Science Approach to Drug Development and Therapy

2016, CPT: Pharmacometrics & Systems Pharmacology

Jörn Lötsch, Alfred Ultsch, Maren Eckhardt, Caroline Huart, Philippe Rombaux, Thomas Hummel

Brain lesion-pattern analysis in patients with olfactory dysfunctions following head trauma

2016, NeuroImage: Clinical

Carmen Walter, Bruno Oertel, Lisa Felden, Christian A. Kell, Ulrike Noth, Johannes Vermehren, Jochen Kaiser, Ralf Deichmann, Jörn Lötsch

Brain Mapping-Based Model of Delta(9)-Tetrahydrocannabinol Effects on Connectivity in the Pain Matrix

2016, Neuropsychopharmacology

Dario Kringel, Alfred Ultsch, Michael Zimmermann, Jan Peter Jansen, Wilfried Ilias, Rainer Freynhagen, Norbert Griessinger, Dr. Andreas Kopf, Christoph Stein, Alexandra Doehring, Eduard Resch, Jörn Lötsch

Emergent biomarker derived from next-generation sequencing to identify pain patients requiring uncommonly high opioid doses

2016, The pharmacogenomics journal

Claudia Knothe, Hiromi Shiratori, Eduard Resch, Alfred Ultsch, Gerd Geisslinger, Alexandra Doehring, Jörn Lötsch

Disagreement between two common biomarkers of global DNA methylation

2016, Clinical epigenetics

Alfred Ultsch, Michael Thrun, Onno Hansen-Goos, Jörn Lötsch

Identification of Molecular Fingerprints in Human Heat Pain Thresholds by Use of an Interactive Mixture Model R Toolbox

2016, International journal of molecular sciences

Claudia Knothe, Bruno Oertel, Alfred Ultsch, Mattias Kettner, Peter Harald Schmidt, Cora Wunder, Stefan W. Toennes, Gerd Geisslinger, Jörn Lötsch

Pharmacoepigenetics of the Role of DNA Methylation in μ-Opioid Receptor Expression in Different Human Brain Regions

2016, Epigenomics

Claudia Knothe, Alexandra Doehring, Alfred Ultsch, Jörn Lötsch

Methadone induces hypermethylation of human DNA

2016, Epigenomics

Jörn Lötsch, Alfred Ultsch

A computational functional genomics based self-limiting self-concentration mechanism of cell specialization as a biological role of jumping genes

2016, Integrative biology : quantitative biosciences from nano to macro

Carmen Walter, Claudia Knothe, Jörn Lötsch

Abuse-Deterrent Opioid Formulations: Pharmacokinetic and Pharmacodynamic Considerations

2016, Clinical pharmacokinetics

Violeta Dimova, Jörn Lötsch, Kathrin Hühne, Andreas Winterpacht, Michael Heesen, Andreas Parthum, Peter G. Weber, Roman Carbon, Norbert Griessinger, Reinhard Sittl

Association of genetic and psychological factors with persistent pain after cosmetic thoracic surgery

2015, Journal of pain research

Jörn Lötsch, Nicole Reither, Vasyl Bogdanov, Antje Hahner, Alfred Ultsch, K Hill, Thomas Hummel

A brain-lesion pattern based algorithm for the diagnosis of posttraumatic olfactory loss

2015, Rhinology

Jörn Lötsch, Claudia Knothe, Catharina Lippmann, Alfred Ultsch, Thomas Hummel, Carmen Walter

Olfactory drug effects approached from human-derived data

2015, Drug discovery today

Jörn Lötsch, Ellen Niederberger, Alfred Ultsch

Computational functional genomics based analysis of pain-relevant micro-RNAs

2015, Human genetics

Jörn Lötsch, Violeta Dimova, Alfred Ultsch, Isabel Lieb, Michael Zimmermann, Gerd Geisslinger, Bruno Oertel